Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis
Abstract Background Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis to clarify the association of TIL-Bs with outcomes of patients with br...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-02004-9 |
| _version_ | 1818435979956977664 |
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| author | You Qin Fei Peng Lisha Ai Shidai Mu Yuting Li Chensu Yang Yu Hu |
| author_facet | You Qin Fei Peng Lisha Ai Shidai Mu Yuting Li Chensu Yang Yu Hu |
| author_sort | You Qin |
| collection | DOAJ |
| description | Abstract Background Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis to clarify the association of TIL-Bs with outcomes of patients with breast cancer. Methods We searched PubMed, Embase, and Web of Science to identify relevant studies assessing the prognostic significance of TIL-Bs in patients with breast cancer. Fixed- or random-effects models were used to evaluate the pooled hazard ratios (HRs) for overall survival (OS), breast cancer-specific survival (BCSS), disease-free survival (DFS), and relapse-free survival (RFS) in breast cancer. Results A total of 8 studies including 2628 patients were included in our study. Pooled analyses revealed that high level of TIL-Bs was associated with longer OS (pooled HR = 0.42, 95% CI 0.24–0.60), BCSS (pooled HR = 0.66, 95% CI 0.47–0.85), and DFS/RFS (pooled HR = 0.41, 95% CI 0.27–0.55). Conclusions This meta-analysis suggests that TIL-Bs could be a promising prognostic marker for breast cancer. Novel therapeutic strategies for breast cancer treatment could be developed by enhancement of B cell-mediated antitumor immunity. |
| first_indexed | 2024-12-14T17:01:30Z |
| format | Article |
| id | doaj.art-345f2637d0054aa9b2f585156c7bc808 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T17:01:30Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-345f2637d0054aa9b2f585156c7bc8082022-12-21T22:53:50ZengBMCCancer Cell International1475-28672021-06-012111810.1186/s12935-021-02004-9Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysisYou Qin0Fei Peng1Lisha Ai2Shidai Mu3Yuting Li4Chensu Yang5Yu Hu6Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis to clarify the association of TIL-Bs with outcomes of patients with breast cancer. Methods We searched PubMed, Embase, and Web of Science to identify relevant studies assessing the prognostic significance of TIL-Bs in patients with breast cancer. Fixed- or random-effects models were used to evaluate the pooled hazard ratios (HRs) for overall survival (OS), breast cancer-specific survival (BCSS), disease-free survival (DFS), and relapse-free survival (RFS) in breast cancer. Results A total of 8 studies including 2628 patients were included in our study. Pooled analyses revealed that high level of TIL-Bs was associated with longer OS (pooled HR = 0.42, 95% CI 0.24–0.60), BCSS (pooled HR = 0.66, 95% CI 0.47–0.85), and DFS/RFS (pooled HR = 0.41, 95% CI 0.27–0.55). Conclusions This meta-analysis suggests that TIL-Bs could be a promising prognostic marker for breast cancer. Novel therapeutic strategies for breast cancer treatment could be developed by enhancement of B cell-mediated antitumor immunity.https://doi.org/10.1186/s12935-021-02004-9Tumor-infiltrating B lymphocytesBreast cancerMeta-analysisPrognosis |
| spellingShingle | You Qin Fei Peng Lisha Ai Shidai Mu Yuting Li Chensu Yang Yu Hu Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis Cancer Cell International Tumor-infiltrating B lymphocytes Breast cancer Meta-analysis Prognosis |
| title | Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis |
| title_full | Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis |
| title_fullStr | Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis |
| title_short | Tumor-infiltrating B cells as a favorable prognostic biomarker in breast cancer: a systematic review and meta-analysis |
| title_sort | tumor infiltrating b cells as a favorable prognostic biomarker in breast cancer a systematic review and meta analysis |
| topic | Tumor-infiltrating B lymphocytes Breast cancer Meta-analysis Prognosis |
| url | https://doi.org/10.1186/s12935-021-02004-9 |
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