Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or Drosophila spartin extends chronologic...

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Bibliographic Details
Main Authors: Julia Ring, Patrick Rockenfeller, Claudia Abraham, Jelena Tadic, Michael Poglitsch, Katherina Schimmel, Julia Westermayer, Simon Schauer, Bettina Achleitner, Christa Schimpel, Barbara Moitzi, Gerald N. Rechberger, Stephan J. Sigrist, Didac Carmona-Gutierrez, Guido Kroemer, Sabrina Büttner, Tobias Eisenberg, Frank Madeo
Format: Article
Language:English
Published: Shared Science Publishers OG 2017-11-01
Series:Microbial Cell
Subjects:
SPG20
mitochondria
metabolism
respiration
pyruvate dehydrogenase
cell death
aging
Online Access:http://microbialcell.com/researcharticles/mitochondrial-energy-metabolism-is-required-for-lifespan-extension-by-the-spastic-paraplegia-associated-protein-spartin/

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