Spermatocytic Tumor: A Review
Spermatocytic tumor (ST) is a very rare disease, accounting for approximately 1% of testicular cancers. Previously classified as spermatocytic seminoma, it is currently classified within the non-germ neoplasia in-situ-derived tumors and has different clinical-pathologic features when compared with o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9529 |
| _version_ | 1797597384643969024 |
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| author | Simona Secondino Alessandra Viglio Giuseppe Neri Giulia Galli Carlotta Faverio Federica Mascaro Richard Naspro Giovanni Rosti Paolo Pedrazzoli |
| author_facet | Simona Secondino Alessandra Viglio Giuseppe Neri Giulia Galli Carlotta Faverio Federica Mascaro Richard Naspro Giovanni Rosti Paolo Pedrazzoli |
| author_sort | Simona Secondino |
| collection | DOAJ |
| description | Spermatocytic tumor (ST) is a very rare disease, accounting for approximately 1% of testicular cancers. Previously classified as spermatocytic seminoma, it is currently classified within the non-germ neoplasia in-situ-derived tumors and has different clinical-pathologic features when compared with other forms of germ cell tumors (GCTs). A web-based search of MEDLINE/PubMed library data was performed in order to identify pertinent articles. In the vast majority of cases, STs are diagnosed at stage I and carry a very good prognosis. The treatment of choice is orchiectomy alone. Nevertheless, there are two rare variants of STs having very aggressive behavior, namely anaplastic ST and ST with sarcomatous transformation, that are resistant to systemic treatments and their prognosis is very poor. We have summarized all the epidemiological, pathological and clinical features available in the literature regarding STs that have to be considered as a specific entity compared to other germ GCTs, including seminoma. With the aim of improving the knowledge of this rare disease, an international registry is required. |
| first_indexed | 2024-03-11T03:05:28Z |
| format | Article |
| id | doaj.art-3461e3ceed8f410b905d769e7decdcd2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:28Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3461e3ceed8f410b905d769e7decdcd22023-11-18T08:00:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411952910.3390/ijms24119529Spermatocytic Tumor: A ReviewSimona Secondino0Alessandra Viglio1Giuseppe Neri2Giulia Galli3Carlotta Faverio4Federica Mascaro5Richard Naspro6Giovanni Rosti7Paolo Pedrazzoli8Oncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyAnatomic Pathology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyAnatomic Pathology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyOncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyOncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyOncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyUrology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyOncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyOncology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalySpermatocytic tumor (ST) is a very rare disease, accounting for approximately 1% of testicular cancers. Previously classified as spermatocytic seminoma, it is currently classified within the non-germ neoplasia in-situ-derived tumors and has different clinical-pathologic features when compared with other forms of germ cell tumors (GCTs). A web-based search of MEDLINE/PubMed library data was performed in order to identify pertinent articles. In the vast majority of cases, STs are diagnosed at stage I and carry a very good prognosis. The treatment of choice is orchiectomy alone. Nevertheless, there are two rare variants of STs having very aggressive behavior, namely anaplastic ST and ST with sarcomatous transformation, that are resistant to systemic treatments and their prognosis is very poor. We have summarized all the epidemiological, pathological and clinical features available in the literature regarding STs that have to be considered as a specific entity compared to other germ GCTs, including seminoma. With the aim of improving the knowledge of this rare disease, an international registry is required.https://www.mdpi.com/1422-0067/24/11/9529spermatocytic tumorrare tumorsgerm cell tumors |
| spellingShingle | Simona Secondino Alessandra Viglio Giuseppe Neri Giulia Galli Carlotta Faverio Federica Mascaro Richard Naspro Giovanni Rosti Paolo Pedrazzoli Spermatocytic Tumor: A Review International Journal of Molecular Sciences spermatocytic tumor rare tumors germ cell tumors |
| title | Spermatocytic Tumor: A Review |
| title_full | Spermatocytic Tumor: A Review |
| title_fullStr | Spermatocytic Tumor: A Review |
| title_full_unstemmed | Spermatocytic Tumor: A Review |
| title_short | Spermatocytic Tumor: A Review |
| title_sort | spermatocytic tumor a review |
| topic | spermatocytic tumor rare tumors germ cell tumors |
| url | https://www.mdpi.com/1422-0067/24/11/9529 |
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