The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1

The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1

The molecular identification of sortilin, also called neurotensin receptor-3, from three different biochemical approaches already predicted the involvement of the protein in numerous biological and cellular functions. The first important observation was that sortilin is synthesized as a precursor th...

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Bibliographic Details
Main Authors: Jean Mazella, Marc Borsotto, Catherine Heurteaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
sortilin
TREK-1 channel
depression
protein complex
spadin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01541/full

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