Mesenchymal stem cells—the master immunomodulators
Mesenchymal stem/stromal cells (MSCs) are known as multipotent cells due to their ability to differentiate into various cell lineages of mesoderm origin. Recent developments in stem cell biology have provided a new ray of hope for the treatment of diseases and disorders that are yet to be treated. T...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-04-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/Journals/ei/Article/100392 |
| _version_ | 1797831604662435840 |
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| author | Mehak Vohra Sunil K. Arora |
| author_facet | Mehak Vohra Sunil K. Arora |
| author_sort | Mehak Vohra |
| collection | DOAJ |
| description | Mesenchymal stem/stromal cells (MSCs) are known as multipotent cells due to their ability to differentiate into various cell lineages of mesoderm origin. Recent developments in stem cell biology have provided a new ray of hope for the treatment of diseases and disorders that are yet to be treated. These cells have been widely used in animals and clinical trials in humans. To date, there are more than 920 clinical trials on humans related to MSCs as cell-based therapy in various conditions. The purpose of this review is to provide a summary of the characteristics of MSCs, evaluate their immunological properties, activation of MSCs that dictate their soluble factors, possible pathway, and mechanisms involved by MSCs and immune cell interaction, and various application of MSCs in different diseases. |
| first_indexed | 2024-04-09T13:54:21Z |
| format | Article |
| id | doaj.art-3463414c87224bac9572e73fc3014841 |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-04-09T13:54:21Z |
| publishDate | 2023-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-3463414c87224bac9572e73fc30148412023-05-08T09:10:26ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552023-04-013210412210.37349/ei.2023.00092Mesenchymal stem cells—the master immunomodulatorsMehak Vohra0https://orcid.org/0009-0000-7852-6297Sunil K. Arora1https://orcid.org/0000-0002-8294-5360Department of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaMesenchymal stem/stromal cells (MSCs) are known as multipotent cells due to their ability to differentiate into various cell lineages of mesoderm origin. Recent developments in stem cell biology have provided a new ray of hope for the treatment of diseases and disorders that are yet to be treated. These cells have been widely used in animals and clinical trials in humans. To date, there are more than 920 clinical trials on humans related to MSCs as cell-based therapy in various conditions. The purpose of this review is to provide a summary of the characteristics of MSCs, evaluate their immunological properties, activation of MSCs that dictate their soluble factors, possible pathway, and mechanisms involved by MSCs and immune cell interaction, and various application of MSCs in different diseases.https://www.explorationpub.com/Journals/ei/Article/100392mesenchymal stem cellsimmunomodulationregenerative medicineanimal modelcell-based therapy |
| spellingShingle | Mehak Vohra Sunil K. Arora Mesenchymal stem cells—the master immunomodulators Exploration of Immunology mesenchymal stem cells immunomodulation regenerative medicine animal model cell-based therapy |
| title | Mesenchymal stem cells—the master immunomodulators |
| title_full | Mesenchymal stem cells—the master immunomodulators |
| title_fullStr | Mesenchymal stem cells—the master immunomodulators |
| title_full_unstemmed | Mesenchymal stem cells—the master immunomodulators |
| title_short | Mesenchymal stem cells—the master immunomodulators |
| title_sort | mesenchymal stem cells the master immunomodulators |
| topic | mesenchymal stem cells immunomodulation regenerative medicine animal model cell-based therapy |
| url | https://www.explorationpub.com/Journals/ei/Article/100392 |
| work_keys_str_mv | AT mehakvohra mesenchymalstemcellsthemasterimmunomodulators AT sunilkarora mesenchymalstemcellsthemasterimmunomodulators |