Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy
Pacemaker (PM)-related thrombosis is an infrequent complication of pacing. We present the case of a 58-year-old man with heart failure and atrial fibrillation who had recurrent episodes of PM lead thrombosis while undergoing anticoagulation therapy. The patient was admitted to the hospital with comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2013-02-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03266 |
| _version_ | 1797922372850810880 |
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| author | S. Selim Ayhan Serkan Öztürk Mehmet Fatih Özlü Selma Düzenli |
| author_facet | S. Selim Ayhan Serkan Öztürk Mehmet Fatih Özlü Selma Düzenli |
| author_sort | S. Selim Ayhan |
| collection | DOAJ |
| description | Pacemaker (PM)-related thrombosis is an infrequent complication of pacing. We present the case of a 58-year-old man with heart failure and atrial fibrillation who had recurrent episodes of PM lead thrombosis while undergoing anticoagulation therapy. The patient was admitted to the hospital with complaints of dyspnea and palpitation. Echocardiography revealed normal right ventricular dimensions and an enlarged left ventricle with poor contractility and an ejection fraction of 20%. Transesophageal echocardiography demonstrated a large, mobile thrombus in the right atrium that was attached to the PM lead. The patient was successfully treated with a thrombolytic agent. Genetic tests revealed that the patient was a heterozygous carrier of the methylenetetrahydrofolate reductase (MTHFR) gene mutation. |
| first_indexed | 2024-04-10T14:30:22Z |
| format | Article |
| id | doaj.art-34638e689e124e7b82fd7030cea60fd4 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T14:30:22Z |
| publishDate | 2013-02-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-34638e689e124e7b82fd7030cea60fd42023-02-15T16:08:49ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692013-02-01411646710.5543/tkda.2013.03266TKDA-03266Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapyS. Selim Ayhan0Serkan Öztürk1Mehmet Fatih Özlü2Selma Düzenli3Department of Cardiology, Abant Izzet Baysal University Faculty of Medicine, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine, Bolu, TurkeyDepartment of Medical Biology and Genetics, Abant Izzet Baysal University Faculty of Medicine, Bolu, TurkeyPacemaker (PM)-related thrombosis is an infrequent complication of pacing. We present the case of a 58-year-old man with heart failure and atrial fibrillation who had recurrent episodes of PM lead thrombosis while undergoing anticoagulation therapy. The patient was admitted to the hospital with complaints of dyspnea and palpitation. Echocardiography revealed normal right ventricular dimensions and an enlarged left ventricle with poor contractility and an ejection fraction of 20%. Transesophageal echocardiography demonstrated a large, mobile thrombus in the right atrium that was attached to the PM lead. The patient was successfully treated with a thrombolytic agent. Genetic tests revealed that the patient was a heterozygous carrier of the methylenetetrahydrofolate reductase (MTHFR) gene mutation.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03266echocardiographymethylenetetrahydrofolate reductase; pacemakerartificial/adverse effects; prosthesis failure; thrombolytic therapy; venous thrombosis/diagnosis; heart diseases. |
| spellingShingle | S. Selim Ayhan Serkan Öztürk Mehmet Fatih Özlü Selma Düzenli Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy Türk Kardiyoloji Derneği Arşivi echocardiography methylenetetrahydrofolate reductase; pacemaker artificial/adverse effects; prosthesis failure; thrombolytic therapy; venous thrombosis/diagnosis; heart diseases. |
| title | Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy |
| title_full | Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy |
| title_fullStr | Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy |
| title_full_unstemmed | Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy |
| title_short | Recurrent pacemaker lead thrombosis in a patient with gene polymorphism: a rare case treated with thrombolytic therapy |
| title_sort | recurrent pacemaker lead thrombosis in a patient with gene polymorphism a rare case treated with thrombolytic therapy |
| topic | echocardiography methylenetetrahydrofolate reductase; pacemaker artificial/adverse effects; prosthesis failure; thrombolytic therapy; venous thrombosis/diagnosis; heart diseases. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03266 |
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