Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging
ObjectiveThe purpose of this study was to study mechanisms of VNS modulation from a single neuron perspective utilizing a practical observation platform with single neuron resolution and widefield, real-time imaging coupled with an animal model simultaneously exposing the cerebral cortex and the hip...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1131063/full |
| _version_ | 1811161898661445632 |
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| author | Hanyun Xu Hanyun Xu Tingting Jin Rujin Zhang Hao Xie Chaowei Zhuang Yanyang Zhang Dongsheng Kong Guihua Xiao Guihua Xiao Xinguang Yu |
| author_facet | Hanyun Xu Hanyun Xu Tingting Jin Rujin Zhang Hao Xie Chaowei Zhuang Yanyang Zhang Dongsheng Kong Guihua Xiao Guihua Xiao Xinguang Yu |
| author_sort | Hanyun Xu |
| collection | DOAJ |
| description | ObjectiveThe purpose of this study was to study mechanisms of VNS modulation from a single neuron perspective utilizing a practical observation platform with single neuron resolution and widefield, real-time imaging coupled with an animal model simultaneously exposing the cerebral cortex and the hippocampus.MethodsWe utilized the observation platform characterized of widefield of view, real-time imaging, and high spatiotemporal resolution to obtain the neuronal activities in the cerebral cortex and the hippocampus during VNS in awake states and under anesthesia.ResultsSome neurons in the hippocampus were tightly related to VNS modulation, and varied types of neurons showed distinct responses to VNS modulation.ConclusionWe utilized such an observation platform coupled with a novel animal model to obtain more information on neuron activities in the cerebral cortex and the hippocampus, providing an effective method to further study the mechanisms of therapeutic effects modulated by VNS. |
| first_indexed | 2024-04-10T06:21:25Z |
| format | Article |
| id | doaj.art-3465ea6966f34c2ea38b11f4ec710d21 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T06:21:25Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-3465ea6966f34c2ea38b11f4ec710d212023-03-02T04:32:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11310631131063Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imagingHanyun Xu0Hanyun Xu1Tingting Jin2Rujin Zhang3Hao Xie4Chaowei Zhuang5Yanyang Zhang6Dongsheng Kong7Guihua Xiao8Guihua Xiao9Xinguang Yu10Chinese PLA Medical School, Beijing, ChinaDepartment of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaPulmonary and Critical Care Department, Wuhu Hospital of East China Normal University, Wuhu, Anhui, ChinaDepartment of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Automation, Tsinghua University, Beijing, ChinaDepartment of Automation, Tsinghua University, Beijing, ChinaDepartment of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Automation, Tsinghua University, Beijing, ChinaBNRist, Tsinghua University, Beijing, ChinaDepartment of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaObjectiveThe purpose of this study was to study mechanisms of VNS modulation from a single neuron perspective utilizing a practical observation platform with single neuron resolution and widefield, real-time imaging coupled with an animal model simultaneously exposing the cerebral cortex and the hippocampus.MethodsWe utilized the observation platform characterized of widefield of view, real-time imaging, and high spatiotemporal resolution to obtain the neuronal activities in the cerebral cortex and the hippocampus during VNS in awake states and under anesthesia.ResultsSome neurons in the hippocampus were tightly related to VNS modulation, and varied types of neurons showed distinct responses to VNS modulation.ConclusionWe utilized such an observation platform coupled with a novel animal model to obtain more information on neuron activities in the cerebral cortex and the hippocampus, providing an effective method to further study the mechanisms of therapeutic effects modulated by VNS.https://www.frontiersin.org/articles/10.3389/fnins.2023.1131063/fullvagus nerve stimulationin vivo imaginghippocampuscerebral cortexneuronal activityfluorescence microscope |
| spellingShingle | Hanyun Xu Hanyun Xu Tingting Jin Rujin Zhang Hao Xie Chaowei Zhuang Yanyang Zhang Dongsheng Kong Guihua Xiao Guihua Xiao Xinguang Yu Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging Frontiers in Neuroscience vagus nerve stimulation in vivo imaging hippocampus cerebral cortex neuronal activity fluorescence microscope |
| title | Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging |
| title_full | Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging |
| title_fullStr | Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging |
| title_full_unstemmed | Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging |
| title_short | Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large-scale imaging |
| title_sort | cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under in vivo large scale imaging |
| topic | vagus nerve stimulation in vivo imaging hippocampus cerebral cortex neuronal activity fluorescence microscope |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1131063/full |
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