Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02740-5 |
| _version_ | 1818994693578424320 |
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| author | Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle |
| author_facet | Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle |
| author_sort | Milica Tosic |
| collection | DOAJ |
| description | Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice. |
| first_indexed | 2024-12-20T21:02:00Z |
| format | Article |
| id | doaj.art-3468bea8b20d48ef8bf865d12864b2d3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:02:00Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3468bea8b20d48ef8bf865d12864b2d32022-12-21T19:26:40ZengNature PortfolioNature Communications2041-17232018-01-019111410.1038/s41467-017-02740-5Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cellsMilica Tosic0Anita Allen1Dominica Willmann2Christoph Lepper3Johnny Kim4Delphine Duteil5Roland Schüle6Urologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgDepartment of Embryology, Carnegie InstitutionDepartment of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung ResearchUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgSatellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.https://doi.org/10.1038/s41467-017-02740-5 |
| spellingShingle | Milica Tosic Anita Allen Dominica Willmann Christoph Lepper Johnny Kim Delphine Duteil Roland Schüle Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells Nature Communications |
| title | Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| title_full | Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| title_fullStr | Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| title_full_unstemmed | Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| title_short | Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| title_sort | lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells |
| url | https://doi.org/10.1038/s41467-017-02740-5 |
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