Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid
AbstractMethotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2015-06-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/abd/v90n3s1/0365-0596-abd-90-03-s1-0043.pdf |
| _version_ | 1818743483150630912 |
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| author | Haibo Liu Fang Liu Min Zhang Wenliang Yan Hong Sang |
| author_facet | Haibo Liu Fang Liu Min Zhang Wenliang Yan Hong Sang |
| author_sort | Haibo Liu |
| collection | DOAJ |
| description | AbstractMethotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined acute pneumonitis and pancytopenia after a cumulative dose of 20 mg methotrexate for bullous pemphigoid. Continuous renal replacement therapy (CRRT) can effi ciently decrease serum methotrexate concentration. A rapid improvement of clinical symptoms and resolution of pulmonary opacifi cation were found after CRRT. Blood cell counts returned to normal after component blood transfusion and cytokine supportive therapy. Patients with impaired renal function are at high risk of methotrexate toxicity, and low-dose methotrexate should be prescribed with great caution. |
| first_indexed | 2024-12-18T02:29:07Z |
| format | Article |
| id | doaj.art-3468fd181eef400190aa3c7872a5ebff |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-18T02:29:07Z |
| publishDate | 2015-06-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-3468fd181eef400190aa3c7872a5ebff2022-12-21T21:23:56ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962015-06-01903 suppl 1434510.1590/abd1806-4841.20153692Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoidHaibo LiuFang LiuMin ZhangWenliang YanHong SangAbstractMethotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined acute pneumonitis and pancytopenia after a cumulative dose of 20 mg methotrexate for bullous pemphigoid. Continuous renal replacement therapy (CRRT) can effi ciently decrease serum methotrexate concentration. A rapid improvement of clinical symptoms and resolution of pulmonary opacifi cation were found after CRRT. Blood cell counts returned to normal after component blood transfusion and cytokine supportive therapy. Patients with impaired renal function are at high risk of methotrexate toxicity, and low-dose methotrexate should be prescribed with great caution.http://www.scielo.br/pdf/abd/v90n3s1/0365-0596-abd-90-03-s1-0043.pdfMethotrexatePancytopeniaPneumoniaRenal dialysis |
| spellingShingle | Haibo Liu Fang Liu Min Zhang Wenliang Yan Hong Sang Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid Anais Brasileiros de Dermatologia Methotrexate Pancytopenia Pneumonia Renal dialysis |
| title | Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| title_full | Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| title_fullStr | Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| title_full_unstemmed | Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| title_short | Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| title_sort | combined acute interstitial pneumonitis and pancytopenia induced by low dose methotrexate in a hemodialysis patient treated for bullous pemphigoid |
| topic | Methotrexate Pancytopenia Pneumonia Renal dialysis |
| url | http://www.scielo.br/pdf/abd/v90n3s1/0365-0596-abd-90-03-s1-0043.pdf |
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