Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan
As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate products and effectors of upstream biological processes. Metabolomics provides accurate information that helps determine the physiological ste...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/5/591 |
| _version_ | 1827740776075886592 |
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| author | Qu Tian M. Gordian Adam Enrique Ozcariz Giovanna Fantoni Nader M. Shehadeh Lisa M. Turek Victoria L. Collingham Mary Kaileh Ruin Moaddel Luigi Ferrucci |
| author_facet | Qu Tian M. Gordian Adam Enrique Ozcariz Giovanna Fantoni Nader M. Shehadeh Lisa M. Turek Victoria L. Collingham Mary Kaileh Ruin Moaddel Luigi Ferrucci |
| author_sort | Qu Tian |
| collection | DOAJ |
| description | As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate products and effectors of upstream biological processes. Metabolomics provides accurate information that helps determine the physiological steady state and biochemical changes during the aging process. To date, reference values of metabolites across the adult lifespan, especially among ethnicity groups, are lacking. The “normal” reference values according to age, sex, and race allow the characterization of whether an individual or a group deviates metabolically from normal aging, encompass a fundamental element in any study aimed at understanding mechanisms at the interface between aging and diseases. In this study, we established a metabolomics reference database from 20–100 years of age from a biracial sample of community-dwelling healthy men and women and examined metabolite associations with age, sex, and race. Reference values from well-selected healthy individuals can contribute to clinical decision-making processes of metabolic or related diseases. |
| first_indexed | 2024-03-11T03:30:09Z |
| format | Article |
| id | doaj.art-346c60fa9aba44c7b85fce58c02c9c0b |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T03:30:09Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-346c60fa9aba44c7b85fce58c02c9c0b2023-11-18T02:25:02ZengMDPI AGMetabolites2218-19892023-04-0113559110.3390/metabo13050591Human Metabolome Reference Database in a Biracial Cohort across the Adult LifespanQu Tian0M. Gordian Adam1Enrique Ozcariz2Giovanna Fantoni3Nader M. Shehadeh4Lisa M. Turek5Victoria L. Collingham6Mary Kaileh7Ruin Moaddel8Luigi Ferrucci9Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21214, USAbiocrates life sciences ag, 6020 Innsbruck, Austriabiocrates life sciences ag, 6020 Innsbruck, AustriaLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USALaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USAClinical Research Unit, National Institute on Aging, Baltimore, MD 21224, USAClinical Research Unit, National Institute on Aging, Baltimore, MD 21224, USALaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USALaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USATranslational Gerontology Branch, National Institute on Aging, Baltimore, MD 21214, USAAs one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate products and effectors of upstream biological processes. Metabolomics provides accurate information that helps determine the physiological steady state and biochemical changes during the aging process. To date, reference values of metabolites across the adult lifespan, especially among ethnicity groups, are lacking. The “normal” reference values according to age, sex, and race allow the characterization of whether an individual or a group deviates metabolically from normal aging, encompass a fundamental element in any study aimed at understanding mechanisms at the interface between aging and diseases. In this study, we established a metabolomics reference database from 20–100 years of age from a biracial sample of community-dwelling healthy men and women and examined metabolite associations with age, sex, and race. Reference values from well-selected healthy individuals can contribute to clinical decision-making processes of metabolic or related diseases.https://www.mdpi.com/2218-1989/13/5/591aginglifespanreference database |
| spellingShingle | Qu Tian M. Gordian Adam Enrique Ozcariz Giovanna Fantoni Nader M. Shehadeh Lisa M. Turek Victoria L. Collingham Mary Kaileh Ruin Moaddel Luigi Ferrucci Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan Metabolites aging lifespan reference database |
| title | Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan |
| title_full | Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan |
| title_fullStr | Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan |
| title_full_unstemmed | Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan |
| title_short | Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan |
| title_sort | human metabolome reference database in a biracial cohort across the adult lifespan |
| topic | aging lifespan reference database |
| url | https://www.mdpi.com/2218-1989/13/5/591 |
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