Insight into the Double-Edged Role of Ferroptosis in Disease
Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highligh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/12/1790 |
| _version_ | 1797506432301531136 |
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| author | Lei Zhang Ruohan Jia Huizhen Li Huarun Yu Keke Ren Shuangshuang Jia Yanzhang Li Qun Wang |
| author_facet | Lei Zhang Ruohan Jia Huizhen Li Huarun Yu Keke Ren Shuangshuang Jia Yanzhang Li Qun Wang |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis. |
| first_indexed | 2024-03-10T04:32:34Z |
| format | Article |
| id | doaj.art-346cdea69ad64da88012b36891cfaa2d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T04:32:34Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-346cdea69ad64da88012b36891cfaa2d2023-11-23T03:59:11ZengMDPI AGBiomolecules2218-273X2021-11-011112179010.3390/biom11121790Insight into the Double-Edged Role of Ferroptosis in DiseaseLei Zhang0Ruohan Jia1Huizhen Li2Huarun Yu3Keke Ren4Shuangshuang Jia5Yanzhang Li6Qun Wang7Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng 475004, ChinaSchool of Clinical Medicine, Henan University, Kaifeng 475004, ChinaSchool of Clinical Medicine, Henan University, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaFerroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.https://www.mdpi.com/2218-273X/11/12/1790ferroptosissystemic diseasesROSinhibitorsinducers |
| spellingShingle | Lei Zhang Ruohan Jia Huizhen Li Huarun Yu Keke Ren Shuangshuang Jia Yanzhang Li Qun Wang Insight into the Double-Edged Role of Ferroptosis in Disease Biomolecules ferroptosis systemic diseases ROS inhibitors inducers |
| title | Insight into the Double-Edged Role of Ferroptosis in Disease |
| title_full | Insight into the Double-Edged Role of Ferroptosis in Disease |
| title_fullStr | Insight into the Double-Edged Role of Ferroptosis in Disease |
| title_full_unstemmed | Insight into the Double-Edged Role of Ferroptosis in Disease |
| title_short | Insight into the Double-Edged Role of Ferroptosis in Disease |
| title_sort | insight into the double edged role of ferroptosis in disease |
| topic | ferroptosis systemic diseases ROS inhibitors inducers |
| url | https://www.mdpi.com/2218-273X/11/12/1790 |
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