Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide
We report herein, the usage of N,O-bis(trimethylsilyl)acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 °C to afford the corresponding 3,4-dihydropyrimidin...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212001141 |
| _version_ | 1819211617785610240 |
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| author | Y.L.N. Murthy Abdul Rajack Kanithi Yuvaraj |
| author_facet | Y.L.N. Murthy Abdul Rajack Kanithi Yuvaraj |
| author_sort | Y.L.N. Murthy |
| collection | DOAJ |
| description | We report herein, the usage of N,O-bis(trimethylsilyl)acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 °C to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones/thiones (DHPMs) in good to excellent yields. A comparative study of these two catalysts was made and presented. |
| first_indexed | 2024-12-23T06:29:55Z |
| format | Article |
| id | doaj.art-346f89dd837b470faeae326e316c2066 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-23T06:29:55Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-346f89dd837b470faeae326e316c20662022-12-21T17:56:57ZengElsevierArabian Journal of Chemistry1878-53522016-11-019S2S1740S174610.1016/j.arabjc.2012.04.046Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimideY.L.N. Murthy0Abdul Rajack1Kanithi Yuvaraj2Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam 530003, IndiaDepartment of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam 530003, IndiaDepartment of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam 530003, IndiaWe report herein, the usage of N,O-bis(trimethylsilyl)acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 °C to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones/thiones (DHPMs) in good to excellent yields. A comparative study of these two catalysts was made and presented.http://www.sciencedirect.com/science/article/pii/S1878535212001141N,O-Bis(trimethylsilyl)acetamideDicyclohexyl carbodimideSolvent free3,4-Dihydropyrimidinones3,4-Dihydropyrimidithiones |
| spellingShingle | Y.L.N. Murthy Abdul Rajack Kanithi Yuvaraj Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide Arabian Journal of Chemistry N,O-Bis(trimethylsilyl)acetamide Dicyclohexyl carbodimide Solvent free 3,4-Dihydropyrimidinones 3,4-Dihydropyrimidithiones |
| title | Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide |
| title_full | Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide |
| title_fullStr | Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide |
| title_full_unstemmed | Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide |
| title_short | Solvent free synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N,O-bis(trimethylsilyl)acetamide and dicyclohexyl carbodimide |
| title_sort | solvent free synthesis of 3 4 dihydropyrimidine 2 1h ones thiones catalyzed by n o bis trimethylsilyl acetamide and dicyclohexyl carbodimide |
| topic | N,O-Bis(trimethylsilyl)acetamide Dicyclohexyl carbodimide Solvent free 3,4-Dihydropyrimidinones 3,4-Dihydropyrimidithiones |
| url | http://www.sciencedirect.com/science/article/pii/S1878535212001141 |
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