Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice

Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice

Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH), is a common hepatic manifestation of metabolic syndrome. However, there are no effective therapy to treat this devastating disease. Accumulating evidence suggests that the generation of elastin-derived peptides...

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Bibliographic Details
Main Authors: Nazi Song, Hongjiao Xu, Shuohan Wu, Suijia Luo, Jingyao Xu, Qian Zhao, Rui Wang, Xianxing Jiang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
NASH
Liver fibrosis
Combination therapy
Mitochondrial function
Mitophagy
Mitochondrial biogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352200418X

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