Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors
Aim and Background: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract against the inflammatory factors affecting acetic acid-induced ulcerative colitis....
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2021-10-01
|
| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-6458-en.html |
| _version_ | 1811189065229271040 |
|---|---|
| author | zakieh keshavarzi Mosa-Al- Reza Hadjzadeh masoud nazari roghaye Arezumand |
| author_facet | zakieh keshavarzi Mosa-Al- Reza Hadjzadeh masoud nazari roghaye Arezumand |
| author_sort | zakieh keshavarzi |
| collection | DOAJ |
| description | Aim and Background: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract against the inflammatory factors affecting acetic acid-induced ulcerative colitis.
Materials and Methods: 32 male Wistar rats are divided into 4 groups of 8 including: control group, untreated colitis group, colitis group treated with aloe vera (200 mg / kg/ day) and sulfasalazine group as a standard treatment (500 mg /kg/ day) from two days before induction of colitis to 5 days after induction of colitis. Experimental colitis was induced by intrarectal injection of 2 ml of 3% acetic acid. Rats were sacrificed on the eighth day of induction of colitis and some factors involved in inflammation, such as tumor necrosis factor-alpha, interleukin-10, cyclooxygenase 2 (COX II) and PGE2 levels in colon tissue were measured.
Results: Inflammation induced in colon by acetic acid injection. Sulfasalazine and aloe vera reduced the inflammatory factor (tumor necrosis factor alpha) and increased anti-inflammatory factor (interleukin-10) in colon tissue. But they had no effect on the COX II and PGE2 levels in colon tissue.
Conclusion: The results suggested that aloe vera could possibly improve colitis by suppressing inflammatory promoting factors and increasing anti-inflammatory factors. |
| first_indexed | 2024-04-11T14:28:33Z |
| format | Article |
| id | doaj.art-3476171060904567bbbb579ec6ff3039 |
| institution | Directory Open Access Journal |
| issn | 1560-652X 2345-4040 |
| language | fas |
| last_indexed | 2024-04-11T14:28:33Z |
| publishDate | 2021-10-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-3476171060904567bbbb579ec6ff30392022-12-22T04:18:43ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402021-10-012646979Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factorszakieh keshavarzi0Mosa-Al- Reza Hadjzadeh1masoud nazari2roghaye Arezumand3 Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. Aim and Background: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract against the inflammatory factors affecting acetic acid-induced ulcerative colitis. Materials and Methods: 32 male Wistar rats are divided into 4 groups of 8 including: control group, untreated colitis group, colitis group treated with aloe vera (200 mg / kg/ day) and sulfasalazine group as a standard treatment (500 mg /kg/ day) from two days before induction of colitis to 5 days after induction of colitis. Experimental colitis was induced by intrarectal injection of 2 ml of 3% acetic acid. Rats were sacrificed on the eighth day of induction of colitis and some factors involved in inflammation, such as tumor necrosis factor-alpha, interleukin-10, cyclooxygenase 2 (COX II) and PGE2 levels in colon tissue were measured. Results: Inflammation induced in colon by acetic acid injection. Sulfasalazine and aloe vera reduced the inflammatory factor (tumor necrosis factor alpha) and increased anti-inflammatory factor (interleukin-10) in colon tissue. But they had no effect on the COX II and PGE2 levels in colon tissue. Conclusion: The results suggested that aloe vera could possibly improve colitis by suppressing inflammatory promoting factors and increasing anti-inflammatory factors.http://sjku.muk.ac.ir/article-1-6458-en.htmlsulfasalazinecox iipge2tumor necrosis factor alphainterleukin 10 |
| spellingShingle | zakieh keshavarzi Mosa-Al- Reza Hadjzadeh masoud nazari roghaye Arezumand Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors مجله علمی دانشگاه علوم پزشکی کردستان sulfasalazine cox ii pge2 tumor necrosis factor alpha interleukin 10 |
| title | Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors |
| title_full | Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors |
| title_fullStr | Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors |
| title_full_unstemmed | Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors |
| title_short | Protective Effect of Aloe Vera Gel in Ulcerative Colitis: The Role of Inflammatory and Anti-Inflammatory Factors |
| title_sort | protective effect of aloe vera gel in ulcerative colitis the role of inflammatory and anti inflammatory factors |
| topic | sulfasalazine cox ii pge2 tumor necrosis factor alpha interleukin 10 |
| url | http://sjku.muk.ac.ir/article-1-6458-en.html |
| work_keys_str_mv | AT zakiehkeshavarzi protectiveeffectofaloeveragelinulcerativecolitistheroleofinflammatoryandantiinflammatoryfactors AT mosaalrezahadjzadeh protectiveeffectofaloeveragelinulcerativecolitistheroleofinflammatoryandantiinflammatoryfactors AT masoudnazari protectiveeffectofaloeveragelinulcerativecolitistheroleofinflammatoryandantiinflammatoryfactors AT roghayearezumand protectiveeffectofaloeveragelinulcerativecolitistheroleofinflammatoryandantiinflammatoryfactors |