2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demon...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23300-y |
| _version_ | 1818344637917560832 |
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| author | Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak |
| author_facet | Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak |
| author_sort | Rafał Szabla |
| collection | DOAJ |
| description | UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demonstrate that both 2,6-diaminopurine and adenine nucleosides can be formed under the same prebiotic conditions. |
| first_indexed | 2024-12-13T16:49:39Z |
| format | Article |
| id | doaj.art-347696f7b33c4b0fa6bc7bc725ea0853 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:49:39Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-347696f7b33c4b0fa6bc7bc725ea08532022-12-21T23:38:04ZengNature PortfolioNature Communications2041-17232021-05-0112111110.1038/s41467-021-23300-y2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditionsRafał Szabla0Magdalena Zdrowowicz1Paulina Spisz2Nicholas J. Green3Petr Stadlbauer4Holger Kruse5Jiří Šponer6Janusz Rak7EaStCHEM School of Chemistry, University of EdinburghFaculty of Chemistry, University of GdańskFaculty of Chemistry, University of GdańskMRC Laboratory of Molecular BiologyInstitute of Biophysics of the Czech Academy of SciencesInstitute of Biophysics of the Czech Academy of SciencesInstitute of Biophysics of the Czech Academy of SciencesFaculty of Chemistry, University of GdańskUV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demonstrate that both 2,6-diaminopurine and adenine nucleosides can be formed under the same prebiotic conditions.https://doi.org/10.1038/s41467-021-23300-y |
| spellingShingle | Rafał Szabla Magdalena Zdrowowicz Paulina Spisz Nicholas J. Green Petr Stadlbauer Holger Kruse Jiří Šponer Janusz Rak 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions Nature Communications |
| title | 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions |
| title_full | 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions |
| title_fullStr | 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions |
| title_full_unstemmed | 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions |
| title_short | 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions |
| title_sort | 2 6 diaminopurine promotes repair of dna lesions under prebiotic conditions |
| url | https://doi.org/10.1038/s41467-021-23300-y |
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