Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide
Se bio-absorption and toxicity of Se-RGP were evaluated and compared with inorganic selenium salt using a mouse model. Antioxidant capacities of Se-RGP and original RGP were compared using in vitro and vivo models. Se-RGP showed low toxicity with MTD over 20 g/kg bw. The mice in Se-RGP treatment had...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619304165 |
| _version_ | 1818953794980937728 |
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| author | Dejing Chen Haiyan Sun Yixiao Shen Ming Luo Xi Xin Zhimin Xu |
| author_facet | Dejing Chen Haiyan Sun Yixiao Shen Ming Luo Xi Xin Zhimin Xu |
| author_sort | Dejing Chen |
| collection | DOAJ |
| description | Se bio-absorption and toxicity of Se-RGP were evaluated and compared with inorganic selenium salt using a mouse model. Antioxidant capacities of Se-RGP and original RGP were compared using in vitro and vivo models. Se-RGP showed low toxicity with MTD over 20 g/kg bw. The mice in Se-RGP treatment had significantly higher Se level in blood, liver, lung, spleen and bone than the mice administered by sodium selenite at a dose close to MLD. In in vitro antioxidant activity assays, Se-RGP exhibited higher activity than RGP, but much lower than VC in scavenging hydroxyl, DPPH, and superoxide free radicals. In in vivo model, the mice in RGP and Se-RGP groups had better SOD and GSH-Px activities, T-AOC and MDA level than the mice in VC group. Se-RGP significantly strengthened the antioxidant capability of original RGP by increasing of SOD and GSH-Px activities and T-AOC in mouse serum, heart, liver, and kidney. |
| first_indexed | 2024-12-20T10:11:56Z |
| format | Article |
| id | doaj.art-347937961160475fa2159f9a955f6071 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T10:11:56Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-347937961160475fa2159f9a955f60712022-12-21T19:44:07ZengElsevierJournal of Functional Foods1756-46462019-10-0161Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharideDejing Chen0Haiyan Sun1Yixiao Shen2Ming Luo3Xi Xin4Zhimin Xu5Shaanxi Key Laboratory of Bioresources, Shaanxi University of Technology, Hanzhong, ChinaShaanxi Key Laboratory of Bioresources, Shaanxi University of Technology, Hanzhong, ChinaSchool of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, USASchool of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, ChinaSchool of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, ChinaSchool of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, USA; Corresponding author at: School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, LA 0803, USA.Se bio-absorption and toxicity of Se-RGP were evaluated and compared with inorganic selenium salt using a mouse model. Antioxidant capacities of Se-RGP and original RGP were compared using in vitro and vivo models. Se-RGP showed low toxicity with MTD over 20 g/kg bw. The mice in Se-RGP treatment had significantly higher Se level in blood, liver, lung, spleen and bone than the mice administered by sodium selenite at a dose close to MLD. In in vitro antioxidant activity assays, Se-RGP exhibited higher activity than RGP, but much lower than VC in scavenging hydroxyl, DPPH, and superoxide free radicals. In in vivo model, the mice in RGP and Se-RGP groups had better SOD and GSH-Px activities, T-AOC and MDA level than the mice in VC group. Se-RGP significantly strengthened the antioxidant capability of original RGP by increasing of SOD and GSH-Px activities and T-AOC in mouse serum, heart, liver, and kidney.http://www.sciencedirect.com/science/article/pii/S1756464619304165SeleniumPolysaccharideRiceAbsorptionAntioxidantToxicity |
| spellingShingle | Dejing Chen Haiyan Sun Yixiao Shen Ming Luo Xi Xin Zhimin Xu Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide Journal of Functional Foods Selenium Polysaccharide Rice Absorption Antioxidant Toxicity |
| title | Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| title_full | Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| title_fullStr | Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| title_full_unstemmed | Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| title_short | Selenium bio-absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| title_sort | selenium bio absorption and antioxidant capacity in mice treated by selenium modified rice germ polysaccharide |
| topic | Selenium Polysaccharide Rice Absorption Antioxidant Toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619304165 |
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