N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors
N6‐methyladenosine (m6A) is the most abundant RNA chemical modification in eukaryotes and is also found in the RNAs of many viruses. In recent years, m6A RNA modification has been reported to have a role not only in the replication of numerous viruses but also in the innate immune escape process. In...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031200/full |
| _version_ | 1811178231061020672 |
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| author | Huanan Li Huanan Li Huanan Li Huanan Li Yang Guo Yang Guo Yang Guo Yang Guo Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao |
| author_facet | Huanan Li Huanan Li Huanan Li Huanan Li Yang Guo Yang Guo Yang Guo Yang Guo Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao |
| author_sort | Huanan Li |
| collection | DOAJ |
| description | N6‐methyladenosine (m6A) is the most abundant RNA chemical modification in eukaryotes and is also found in the RNAs of many viruses. In recent years, m6A RNA modification has been reported to have a role not only in the replication of numerous viruses but also in the innate immune escape process. In this review, we describe the viruses that contain m6A in their genomes or messenger RNAs (mRNAs), and summarize the effects of m6A on the replication of different viruses. We also discuss how m6A modification helps viral RNAs escape recognition by exogenous RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), during viral invasion. Overall, the goal of our review is to summarize how m6A regulates viral replication and facilitates innate immune escape. Furthermore, we elaborate on the potential of m6A as a novel antiviral target. |
| first_indexed | 2024-04-11T06:16:12Z |
| format | Article |
| id | doaj.art-347afa200f694387bac3d2c9f4823a92 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T06:16:12Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-347afa200f694387bac3d2c9f4823a922022-12-22T04:41:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10312001031200N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptorsHuanan Li0Huanan Li1Huanan Li2Huanan Li3Yang Guo4Yang Guo5Yang Guo6Yang Guo7Wenbao Qi8Wenbao Qi9Wenbao Qi10Wenbao Qi11Wenbao Qi12Ming Liao13Ming Liao14Ming Liao15Ming Liao16Ming Liao17Ming Liao18National Avian Influenza Para-Reference Laboratory (Guangzhou), South China Agricultural University, Guangzhou, ChinaKey Laboratory of Zoonosis, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaNational and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangzhou, ChinaKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, ChinaNational Avian Influenza Para-Reference Laboratory (Guangzhou), South China Agricultural University, Guangzhou, ChinaKey Laboratory of Zoonosis, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaNational and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangzhou, ChinaKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, ChinaNational Avian Influenza Para-Reference Laboratory (Guangzhou), South China Agricultural University, Guangzhou, ChinaKey Laboratory of Zoonosis, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaNational and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangzhou, ChinaKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, ChinaGuangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, ChinaNational Avian Influenza Para-Reference Laboratory (Guangzhou), South China Agricultural University, Guangzhou, ChinaKey Laboratory of Zoonosis, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaNational and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangzhou, ChinaKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, ChinaGuangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, ChinaGuangdong Academy of Agricultural Sciences, Guangzhou, ChinaN6‐methyladenosine (m6A) is the most abundant RNA chemical modification in eukaryotes and is also found in the RNAs of many viruses. In recent years, m6A RNA modification has been reported to have a role not only in the replication of numerous viruses but also in the innate immune escape process. In this review, we describe the viruses that contain m6A in their genomes or messenger RNAs (mRNAs), and summarize the effects of m6A on the replication of different viruses. We also discuss how m6A modification helps viral RNAs escape recognition by exogenous RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), during viral invasion. Overall, the goal of our review is to summarize how m6A regulates viral replication and facilitates innate immune escape. Furthermore, we elaborate on the potential of m6A as a novel antiviral target.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031200/fullm6AvirusesreplicationRIG-I-like receptorsinnate immune escape |
| spellingShingle | Huanan Li Huanan Li Huanan Li Huanan Li Yang Guo Yang Guo Yang Guo Yang Guo Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Wenbao Qi Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao Ming Liao N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors Frontiers in Immunology m6A viruses replication RIG-I-like receptors innate immune escape |
| title | N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors |
| title_full | N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors |
| title_fullStr | N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors |
| title_full_unstemmed | N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors |
| title_short | N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors |
| title_sort | n6 methyladenosine modification of viral rna and its role during the recognition process of rig i like receptors |
| topic | m6A viruses replication RIG-I-like receptors innate immune escape |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031200/full |
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