How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate
Adipose-derived stem cells (ASCs) are a subpopulation of mesenchymal stem cells. Compared to bone marrow-derived stem cells, they can be harvested with minimal invasiveness. ASCs can be easily expanded and were shown to be able to differentiate into several clinically relevant cell types. Therefore,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3551 |
| _version_ | 1797620522052222976 |
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| author | Svenja Nellinger Petra Juliane Kluger |
| author_facet | Svenja Nellinger Petra Juliane Kluger |
| author_sort | Svenja Nellinger |
| collection | DOAJ |
| description | Adipose-derived stem cells (ASCs) are a subpopulation of mesenchymal stem cells. Compared to bone marrow-derived stem cells, they can be harvested with minimal invasiveness. ASCs can be easily expanded and were shown to be able to differentiate into several clinically relevant cell types. Therefore, this cell type represents a promising component in various tissue engineering and medical approaches (e.g., cell therapy). In vivo cells are surrounded by the extracellular matrix (ECM) that provides a wide range of tissue-specific physical and chemical cues, such as stiffness, topography, and chemical composition. Cells can sense the characteristics of their ECM and respond to them in a specific cellular behavior (e.g., proliferation or differentiation). Thus, in vitro biomaterial properties represent an important tool to control ASCs behavior. In this review, we give an overview of the current research in the mechanosensing of ASCs and current studies investigating the impact of material stiffens, topography, and chemical modification on ASC behavior. Additionally, we outline the use of natural ECM as a biomaterial and its interaction with ASCs regarding cellular behavior. |
| first_indexed | 2024-03-11T08:42:44Z |
| format | Article |
| id | doaj.art-3480a91412e344408fd1544024211bb5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:42:44Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3480a91412e344408fd1544024211bb52023-11-16T21:01:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244355110.3390/ijms24043551How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell FateSvenja Nellinger0Petra Juliane Kluger1Reutlingen Research Institute, Reutlingen University, 72762 Reutlingen, GermanySchool of Life Sciences, Reutlingen University, 72762 Reutlingen, GermanyAdipose-derived stem cells (ASCs) are a subpopulation of mesenchymal stem cells. Compared to bone marrow-derived stem cells, they can be harvested with minimal invasiveness. ASCs can be easily expanded and were shown to be able to differentiate into several clinically relevant cell types. Therefore, this cell type represents a promising component in various tissue engineering and medical approaches (e.g., cell therapy). In vivo cells are surrounded by the extracellular matrix (ECM) that provides a wide range of tissue-specific physical and chemical cues, such as stiffness, topography, and chemical composition. Cells can sense the characteristics of their ECM and respond to them in a specific cellular behavior (e.g., proliferation or differentiation). Thus, in vitro biomaterial properties represent an important tool to control ASCs behavior. In this review, we give an overview of the current research in the mechanosensing of ASCs and current studies investigating the impact of material stiffens, topography, and chemical modification on ASC behavior. Additionally, we outline the use of natural ECM as a biomaterial and its interaction with ASCs regarding cellular behavior.https://www.mdpi.com/1422-0067/24/4/3551adipose-derived stem cellsbiomaterialsstiffnesstopographymodification |
| spellingShingle | Svenja Nellinger Petra Juliane Kluger How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate International Journal of Molecular Sciences adipose-derived stem cells biomaterials stiffness topography modification |
| title | How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate |
| title_full | How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate |
| title_fullStr | How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate |
| title_full_unstemmed | How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate |
| title_short | How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate |
| title_sort | how mechanical and physicochemical material characteristics influence adipose derived stem cell fate |
| topic | adipose-derived stem cells biomaterials stiffness topography modification |
| url | https://www.mdpi.com/1422-0067/24/4/3551 |
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