Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin
Acne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To circumvent these issues, a new approach has emerg...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/8/2083 |
| _version_ | 1797583470715731968 |
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| author | Julie Leignadier Marie Drago Olivier Lesouhaitier Magalie Barreau Albert Dashi Oliver Worsley Joan Attia-Vigneau |
| author_facet | Julie Leignadier Marie Drago Olivier Lesouhaitier Magalie Barreau Albert Dashi Oliver Worsley Joan Attia-Vigneau |
| author_sort | Julie Leignadier |
| collection | DOAJ |
| description | Acne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To circumvent these issues, a new approach has emerged that involves combating the pathogen <i>Cutibacterium acnes</i> while maintaining the homeostasis of the skin microbiome. Recently, it was shown that the use of a G2 lysine dendrigraft (G2 dendrimer) could specifically decrease the <i>C. acnes</i> phylotype (IAI) involved in acne, compared to non-acne-causing <i>C. acnes</i> (phylotype II) bacteria. In the present study, we demonstrate that the efficacy of this technology is related to its 3D structure, which, in contrast to the linear form, significantly decreases the inflammation factor (IL-8) linked to acne. In addition, our in-vitro data confirm the specific activity of the G2 dendrimer: after treatment of bacterial cultures and biofilms, the G2 dendrimer affected neither non-acneic <i>C. acnes</i> nor commensal bacteria of the skin (<i>Staphylococcus epidermidis</i>, <i>S. hominis,</i> and <i>Corynebacterium minutissimum</i>). In parallel, comparative in-vitro and in-vivo studies with traditional over-the-counter molecules showed G2’s effects on the survival of commensal bacteria and the reduction of acne outbreaks. Finally, metagenomic analysis of the cutaneous microbiota of volunteers who applied a finished cosmetic product containing the G2 dendrimer confirmed the ability of G2 to rebalance cutaneous acne microbiota dysbiosis while maintaining commensal bacteria. These results confirm the value of using this G2 dendrimer to gently prevent the appearance of acne vulgaris while respecting the cutaneous microbiota. |
| first_indexed | 2024-03-10T23:39:21Z |
| format | Article |
| id | doaj.art-34817523271a428c8da51ae7fb744ee1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-34817523271a428c8da51ae7fb744ee12023-11-19T02:36:32ZengMDPI AGPharmaceutics1999-49232023-08-01158208310.3390/pharmaceutics15082083Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone SkinJulie Leignadier0Marie Drago1Olivier Lesouhaitier2Magalie Barreau3Albert Dashi4Oliver Worsley5Joan Attia-Vigneau6Lucas Meyer Cosmetics, 195 Route d’Espagne, 31036 Toulouse, FranceShiseido EMEA, 56A Rue du Faubourg St Honoré, 75008 Paris, FranceResearch Unit Bacterial Communication and Anti-Infectious Strategies (CBSA, UR4312), University of Rouen Normandie, 27000 Evreux, FranceResearch Unit Bacterial Communication and Anti-Infectious Strategies (CBSA, UR4312), University of Rouen Normandie, 27000 Evreux, FranceSequential Skin Ltd., 85 Great Portland Street, London W1W 7LT, UKSequential Skin Ltd., 85 Great Portland Street, London W1W 7LT, UKLucas Meyer Cosmetics, 195 Route d’Espagne, 31036 Toulouse, FranceAcne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To circumvent these issues, a new approach has emerged that involves combating the pathogen <i>Cutibacterium acnes</i> while maintaining the homeostasis of the skin microbiome. Recently, it was shown that the use of a G2 lysine dendrigraft (G2 dendrimer) could specifically decrease the <i>C. acnes</i> phylotype (IAI) involved in acne, compared to non-acne-causing <i>C. acnes</i> (phylotype II) bacteria. In the present study, we demonstrate that the efficacy of this technology is related to its 3D structure, which, in contrast to the linear form, significantly decreases the inflammation factor (IL-8) linked to acne. In addition, our in-vitro data confirm the specific activity of the G2 dendrimer: after treatment of bacterial cultures and biofilms, the G2 dendrimer affected neither non-acneic <i>C. acnes</i> nor commensal bacteria of the skin (<i>Staphylococcus epidermidis</i>, <i>S. hominis,</i> and <i>Corynebacterium minutissimum</i>). In parallel, comparative in-vitro and in-vivo studies with traditional over-the-counter molecules showed G2’s effects on the survival of commensal bacteria and the reduction of acne outbreaks. Finally, metagenomic analysis of the cutaneous microbiota of volunteers who applied a finished cosmetic product containing the G2 dendrimer confirmed the ability of G2 to rebalance cutaneous acne microbiota dysbiosis while maintaining commensal bacteria. These results confirm the value of using this G2 dendrimer to gently prevent the appearance of acne vulgaris while respecting the cutaneous microbiota.https://www.mdpi.com/1999-4923/15/8/2083acnedendrimerlysinemicrobial diversityclinical studiesbiofilm |
| spellingShingle | Julie Leignadier Marie Drago Olivier Lesouhaitier Magalie Barreau Albert Dashi Oliver Worsley Joan Attia-Vigneau Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin Pharmaceutics acne dendrimer lysine microbial diversity clinical studies biofilm |
| title | Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin |
| title_full | Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin |
| title_fullStr | Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin |
| title_full_unstemmed | Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin |
| title_short | Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin |
| title_sort | lysine dendrimer a new non aggressive solution to rebalance the microbiota of acne prone skin |
| topic | acne dendrimer lysine microbial diversity clinical studies biofilm |
| url | https://www.mdpi.com/1999-4923/15/8/2083 |
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