Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease
The study focused on 30 dyslipidemic patients (12 women and 18 men); 16 of them had coronary disease (CD). The concentrations of apoA and apoB were determined in all patients, as well as the calculated ratio between apoA and apoB. As far as inflammatory indicators are concerned, the concentrations o...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2007-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701025J.pdf |
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| author | Jovović Biljana Lečić Nevenka Jelić Marija Damnjanović Goran Đinđić Boris Sokolović Dušan |
| author_facet | Jovović Biljana Lečić Nevenka Jelić Marija Damnjanović Goran Đinđić Boris Sokolović Dušan |
| author_sort | Jovović Biljana |
| collection | DOAJ |
| description | The study focused on 30 dyslipidemic patients (12 women and 18 men); 16 of them had coronary disease (CD). The concentrations of apoA and apoB were determined in all patients, as well as the calculated ratio between apoA and apoB. As far as inflammatory indicators are concerned, the concentrations of sensitive C reactive protein (hsCRP), albumin, fibrinogen, intracellular adhesive molecule (ICAM-1) and vascular adhesive molecule (VCAM -1) were determined. In patients with CD there were considerably higher concentrations of fibrinogen (3.1 ± 1.2 vs. 2.7 ± 0.7 g/L) and VCAM-1 (10.9 ± 3.6 vs. 8.3 ± 2.8 g/L) (p<0.05) while the numerical values of hsCRP and ICAM-1 were not significantly different in relation to the patients without CD. The concentration of apoB and the value of apoB/apoA ratio were considerably higher in patients with CD (1.7 ± 0.8 vs. 1.3 ± 0.4 and 1.3 ± 0.4 vs. 0.9 ± 0.4; p<0.05), whereas the concentration of apoA did not differ in relation to the patients without CD. The research confirmed the significance of the disturbance in the composition of lipoprotein particles and the systemic inflammatory response in the pathogenesis of atherosclerosis, whereas their significant mutual connection was not shown. This indicates their cumulative effect and different mechanisms at the base of these disturbances. |
| first_indexed | 2024-12-14T16:35:59Z |
| format | Article |
| id | doaj.art-34840bf1c1f64d10b2a2a59633502148 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-14T16:35:59Z |
| publishDate | 2007-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-34840bf1c1f64d10b2a2a596335021482022-12-21T22:54:28ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662007-01-0126125280354-34470701025JDisturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary diseaseJovović Biljana0Lečić Nevenka1Jelić Marija2Damnjanović Goran3Đinđić Boris4Sokolović Dušan5https://orcid.org/0000-0001-6586-6428Clinical Biochemical Laboratory, Military Hospital, NišClinical Biochemical Laboratory, Military Hospital, NišClinical Biochemical Laboratory, Military Hospital, NišClinical Biochemical Laboratory, Military Hospital, NišInstitute of Pathophysiology, Medical Faculty, NišInstitute of Biochemistry, Medical Faculty, NišThe study focused on 30 dyslipidemic patients (12 women and 18 men); 16 of them had coronary disease (CD). The concentrations of apoA and apoB were determined in all patients, as well as the calculated ratio between apoA and apoB. As far as inflammatory indicators are concerned, the concentrations of sensitive C reactive protein (hsCRP), albumin, fibrinogen, intracellular adhesive molecule (ICAM-1) and vascular adhesive molecule (VCAM -1) were determined. In patients with CD there were considerably higher concentrations of fibrinogen (3.1 ± 1.2 vs. 2.7 ± 0.7 g/L) and VCAM-1 (10.9 ± 3.6 vs. 8.3 ± 2.8 g/L) (p<0.05) while the numerical values of hsCRP and ICAM-1 were not significantly different in relation to the patients without CD. The concentration of apoB and the value of apoB/apoA ratio were considerably higher in patients with CD (1.7 ± 0.8 vs. 1.3 ± 0.4 and 1.3 ± 0.4 vs. 0.9 ± 0.4; p<0.05), whereas the concentration of apoA did not differ in relation to the patients without CD. The research confirmed the significance of the disturbance in the composition of lipoprotein particles and the systemic inflammatory response in the pathogenesis of atherosclerosis, whereas their significant mutual connection was not shown. This indicates their cumulative effect and different mechanisms at the base of these disturbances.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701025J.pdfalbumincoronary diseasefibrinogenhcrpicam-1lipoproteinsvcam-1 |
| spellingShingle | Jovović Biljana Lečić Nevenka Jelić Marija Damnjanović Goran Đinđić Boris Sokolović Dušan Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease Journal of Medical Biochemistry albumin coronary disease fibrinogen hcrp icam-1 lipoproteins vcam-1 |
| title | Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| title_full | Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| title_fullStr | Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| title_full_unstemmed | Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| title_short | Disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| title_sort | disturbance in the composition of lipoprotein particles and chronic inflammation as prognostic factors in the development of coronary disease |
| topic | albumin coronary disease fibrinogen hcrp icam-1 lipoproteins vcam-1 |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701025J.pdf |
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