Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients
(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of herpes viruses and polyomavi...
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MDPI AG
2021-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/19/9356 |
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| author | Ramona Gabriela Ursu Ionut Luchian Nicolae Ghetu Victor Vlad Costan Ovidiu Stamatin Octavian Dragos Palade Costin Damian Luminita Smaranda Iancu Elena Porumb-Andrese |
| author_facet | Ramona Gabriela Ursu Ionut Luchian Nicolae Ghetu Victor Vlad Costan Ovidiu Stamatin Octavian Dragos Palade Costin Damian Luminita Smaranda Iancu Elena Porumb-Andrese |
| author_sort | Ramona Gabriela Ursu |
| collection | DOAJ |
| description | (1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of herpes viruses and polyomaviruses in these types of cancer. We aim to evaluate the association of oncogenic viruses from <i>Papillomaviridae, Herpesviridae,</i> and <i>Polyomaviridae</i> families in HNSCCs and skin cancers. (2) Methods: A total of 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR genotyping assay. (3) Results: A total of 23/26 (88.5%) samples were positive for one or more viruses. All the tested tumors were negative for any HPV (alpha or beta types). In total, we detected as positive samples: 16 (61.63%) EBV1, 12 (46.15%) HHV7, 8 (30.76%) MCV, 6 (23.07%) CMV and HHV6, 2 (7.69%) HHV8, 1 (3.8%) HPyV6 and EBV2. (4) Conclusions: We detected HPV-negative cases that are HPyV and HHV positive. In these fractions of HPV-negative HNSCCs cases, other oncogenic viruses may be involved, such as EBV1, MCV or CMV. Additional research is required for clarifying the natural history of these viruses in HNSCCs, as virus detection would have a decisive impact on diagnostic and decisional algorithms. |
| first_indexed | 2024-03-10T07:05:34Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T07:05:34Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-3484d02e229549f49e2266d69ddcbb782023-11-22T15:51:31ZengMDPI AGApplied Sciences2076-34172021-10-011119935610.3390/app11199356Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian PatientsRamona Gabriela Ursu0Ionut Luchian1Nicolae Ghetu2Victor Vlad Costan3Ovidiu Stamatin4Octavian Dragos Palade5Costin Damian6Luminita Smaranda Iancu7Elena Porumb-Andrese8Discipline of Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, RomaniaDepartment of Periodontology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Plastic Surgery, Regional Oncology Institute, 700483 Iaşi, RomaniaDiscipline of Oro-Maxillo-Facial Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaDiscipline of Oro-Maxillo-Facial Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaDepartment of ENT, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, RomaniaDiscipline of Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, RomaniaDiscipline of Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, RomaniaDepartment of Dermatology, “Sf. Spiridon” Clinical Emergency County Hospital, 700111 Iaşi, Romania(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of herpes viruses and polyomaviruses in these types of cancer. We aim to evaluate the association of oncogenic viruses from <i>Papillomaviridae, Herpesviridae,</i> and <i>Polyomaviridae</i> families in HNSCCs and skin cancers. (2) Methods: A total of 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR genotyping assay. (3) Results: A total of 23/26 (88.5%) samples were positive for one or more viruses. All the tested tumors were negative for any HPV (alpha or beta types). In total, we detected as positive samples: 16 (61.63%) EBV1, 12 (46.15%) HHV7, 8 (30.76%) MCV, 6 (23.07%) CMV and HHV6, 2 (7.69%) HHV8, 1 (3.8%) HPyV6 and EBV2. (4) Conclusions: We detected HPV-negative cases that are HPyV and HHV positive. In these fractions of HPV-negative HNSCCs cases, other oncogenic viruses may be involved, such as EBV1, MCV or CMV. Additional research is required for clarifying the natural history of these viruses in HNSCCs, as virus detection would have a decisive impact on diagnostic and decisional algorithms.https://www.mdpi.com/2076-3417/11/19/9356oncogenic viruscriteria for carcinogenicityscreeningclinical utility |
| spellingShingle | Ramona Gabriela Ursu Ionut Luchian Nicolae Ghetu Victor Vlad Costan Ovidiu Stamatin Octavian Dragos Palade Costin Damian Luminita Smaranda Iancu Elena Porumb-Andrese Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients Applied Sciences oncogenic virus criteria for carcinogenicity screening clinical utility |
| title | Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients |
| title_full | Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients |
| title_fullStr | Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients |
| title_full_unstemmed | Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients |
| title_short | Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients |
| title_sort | emerging oncogenic viruses in head and neck cancers from romanian patients |
| topic | oncogenic virus criteria for carcinogenicity screening clinical utility |
| url | https://www.mdpi.com/2076-3417/11/19/9356 |
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