Ranolazine-Mediated Attenuation of Mechanoelectric Feedback in Atrial Myocyte Monolayers

Ranolazine-Mediated Attenuation of Mechanoelectric Feedback in Atrial Myocyte Monolayers

BackgroundMechanical stretch increases Na+ inflow into myocytes, related to mechanisms including stretch-activated channels or Na+/H+ exchanger activation, involving Ca2+ increase that leads to changes in electrophysiological properties favoring arrhythmia induction. Ranolazine is an antianginal dru...

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Bibliographic Details
Main Authors: Irene Del-Canto, Lidia Gómez-Cid, Ismael Hernández-Romero, María S. Guillem, María Eugenia Fernández-Santos, Felipe Atienza, Luis Such, Francisco Fernández-Avilés, Francisco J. Chorro, Andreu M. Climent
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
mechanical stretch
mechanoelectric feedback
fibrillatory patterns
ranolazine
optical mapping
rotor dynamic analysis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00922/full

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