Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Abstract Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of rheumatic diseases, predominantly in systemic juvenile idiopathic arthritis (SJIA), and is considered as an autoinflammatory disease. Specific cytokine profiles could play a pivotal role in this inflammatory...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00907-7 |
| _version_ | 1827724033599209472 |
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| author | Meiping Lu Liping Teng Yiping Xu Xuefeng Xu |
| author_facet | Meiping Lu Liping Teng Yiping Xu Xuefeng Xu |
| author_sort | Meiping Lu |
| collection | DOAJ |
| description | Abstract Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of rheumatic diseases, predominantly in systemic juvenile idiopathic arthritis (SJIA), and is considered as an autoinflammatory disease. Specific cytokine profiles could play a pivotal role in this inflammatory response. Gram-negative bacteremia, bacterial pneumonia, Kawasaki disease, and active SJIA exhibited similar cytokine profiles with elevated interleukin-6 (IL-6) and/or IL-10, further suggesting a correlation between them. Only when JIA is complicated by MAS can increased interferon-γ (IFN-γ) levels be observed. Therefore, increased serum IFN-γ levels could contribute to early diagnosing MAS in patients with SJIA in combination with other variables such as serum ferritin. A prospective multi-center study will be performed to further confirm the role of IFN-γ in the early recognition of MAS in SJIA. |
| first_indexed | 2024-03-10T22:09:10Z |
| format | Article |
| id | doaj.art-34853b8934e14eb48061fed740e8fb48 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-03-10T22:09:10Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-34853b8934e14eb48061fed740e8fb482023-11-19T12:39:59ZengBMCPediatric Rheumatology Online Journal1546-00962023-10-012111310.1186/s12969-023-00907-7Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritisMeiping Lu0Liping Teng1Yiping Xu2Xuefeng Xu3Department of Rheumatology Immunology & Allergy, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child HealthDepartment of Rheumatology Immunology & Allergy, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child HealthDepartment of Rheumatology Immunology & Allergy, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child HealthDepartment of Rheumatology Immunology & Allergy, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child HealthAbstract Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of rheumatic diseases, predominantly in systemic juvenile idiopathic arthritis (SJIA), and is considered as an autoinflammatory disease. Specific cytokine profiles could play a pivotal role in this inflammatory response. Gram-negative bacteremia, bacterial pneumonia, Kawasaki disease, and active SJIA exhibited similar cytokine profiles with elevated interleukin-6 (IL-6) and/or IL-10, further suggesting a correlation between them. Only when JIA is complicated by MAS can increased interferon-γ (IFN-γ) levels be observed. Therefore, increased serum IFN-γ levels could contribute to early diagnosing MAS in patients with SJIA in combination with other variables such as serum ferritin. A prospective multi-center study will be performed to further confirm the role of IFN-γ in the early recognition of MAS in SJIA.https://doi.org/10.1186/s12969-023-00907-7Autoinflammatory DiseaseCytokineDiagnosisMacrophage activation syndromeSystemic juvenile idiopathic arthritis |
| spellingShingle | Meiping Lu Liping Teng Yiping Xu Xuefeng Xu Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis Pediatric Rheumatology Online Journal Autoinflammatory Disease Cytokine Diagnosis Macrophage activation syndrome Systemic juvenile idiopathic arthritis |
| title | Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| title_full | Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| title_fullStr | Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| title_full_unstemmed | Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| title_short | Performance of interferon-gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| title_sort | performance of interferon gamma levels may lead to earlier diagnosing macrophage activation syndrome complicating systemic juvenile idiopathic arthritis |
| topic | Autoinflammatory Disease Cytokine Diagnosis Macrophage activation syndrome Systemic juvenile idiopathic arthritis |
| url | https://doi.org/10.1186/s12969-023-00907-7 |
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