The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-cura...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2012-09-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019&lng=en&tlng=en |
| _version_ | 1797713405918838784 |
|---|---|
| author | Giovanny Garavito Stéphane Bertani Miguel Quiliano Alexis Valentin Ignacio Aldana Eric Deharo |
| author_facet | Giovanny Garavito Stéphane Bertani Miguel Quiliano Alexis Valentin Ignacio Aldana Eric Deharo |
| author_sort | Giovanny Garavito |
| collection | DOAJ |
| description | The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. |
| first_indexed | 2024-03-12T07:37:10Z |
| format | Article |
| id | doaj.art-348599eae07549de94e3de30425b7b0c |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:37:10Z |
| publishDate | 2012-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-348599eae07549de94e3de30425b7b0c2023-09-02T21:28:49ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-09-01107682082310.1590/S0074-02762012000600019S0074-02762012000600019The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinineGiovanny Garavito0Stéphane Bertani1Miguel Quiliano2Alexis Valentin3Ignacio Aldana4Eric Deharo5Universidad Nacional de ColombiaUniversité de ToulouseUniversidad de NavarraUniversité de ToulouseUniversidad de NavarraUniversité de ToulouseThe effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019&lng=en&tlng=enantimalarialsmethylene bluedrug combination |
| spellingShingle | Giovanny Garavito Stéphane Bertani Miguel Quiliano Alexis Valentin Ignacio Aldana Eric Deharo The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine Memorias do Instituto Oswaldo Cruz antimalarials methylene blue drug combination |
| title | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
| title_full | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
| title_fullStr | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
| title_full_unstemmed | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
| title_short | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
| title_sort | in vivo antimalarial activity of methylene blue combined with pyrimethamine chloroquine and quinine |
| topic | antimalarials methylene blue drug combination |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019&lng=en&tlng=en |
| work_keys_str_mv | AT giovannygaravito theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT stephanebertani theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT miguelquiliano theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT alexisvalentin theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT ignacioaldana theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT ericdeharo theinvivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT giovannygaravito invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT stephanebertani invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT miguelquiliano invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT alexisvalentin invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT ignacioaldana invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine AT ericdeharo invivoantimalarialactivityofmethylenebluecombinedwithpyrimethaminechloroquineandquinine |