Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression
AbstractBackground The treatment of hepatic hemangioma includes surgical resection, radiofrequency ablation and Transarterial embolization. However, complications, mortality and compromised effectiveness limit their applications. Microwaves with effective heating generation and short ablation time b...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2146214 |
| _version_ | 1797374209059454976 |
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| author | Li Fei Xing Hongsong |
| author_facet | Li Fei Xing Hongsong |
| author_sort | Li Fei |
| collection | DOAJ |
| description | AbstractBackground The treatment of hepatic hemangioma includes surgical resection, radiofrequency ablation and Transarterial embolization. However, complications, mortality and compromised effectiveness limit their applications. Microwaves with effective heating generation and short ablation time become a promising treatment. The aim of this study is to conduct systematic review and meta-analyses to evaluate the effectiveness of Microwave Ablation (MWA) for the treatment of hepatic hemangioma.Methods A systematic literature review was conducted in PubMed. Main outcomes were defined as hemangioma decreases in diameters and volume changes post-MWA. Conventional random-effect meta-analysis technique was applied to analyze the pooled data, and meta-regression model was established to explore the association among factors.Results There were nine studies with a total of 501 patients retrieved. The pooled estimate of mean differences and 95% CI of hemangioma decreases after MWA treatment in diameter and in volume change (%) were 3.009 cm and (1.856, 4.161), and 53.169% and (51.274, 55.065), respectively. The pooled estimates of liver enzyme, ALT and AST, elevation were 219.905 with 95%CI (160.860, 278.949) and 315.679 with 95%CI (226.961, 404.397), respectively. Major complications were defined as acute kidney injury (AKI), pleural effusion, diaphragmatic hernia, and jaundice that needed to be treated, and the pooled incidence was 0.017 with 95% CI of (0.006, 0.029). No mortality related to MWA was reported. Meta-regression showed ablation time was associated with pre-operative lesion size (p = .001).Conclusion MWA is effective and safe in treatment of hepatic hemangioma, and our study suggests that hemangioma size should be investigated in the future MWA pretreatment difficulty scoring system study. |
| first_indexed | 2024-03-08T19:02:34Z |
| format | Article |
| id | doaj.art-348832b031c048e4b58d80f0f1957cd5 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:34Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-348832b031c048e4b58d80f0f1957cd52023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2022.2146214Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regressionLi Fei0Xing Hongsong1Department of Hepatobiliary and Pancreatic Surgery, Ward 2, PUREN Hospital Affiliated to WUHAN University of Science and Technology, Wuhan, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ward 2, PUREN Hospital Affiliated to WUHAN University of Science and Technology, Wuhan, ChinaAbstractBackground The treatment of hepatic hemangioma includes surgical resection, radiofrequency ablation and Transarterial embolization. However, complications, mortality and compromised effectiveness limit their applications. Microwaves with effective heating generation and short ablation time become a promising treatment. The aim of this study is to conduct systematic review and meta-analyses to evaluate the effectiveness of Microwave Ablation (MWA) for the treatment of hepatic hemangioma.Methods A systematic literature review was conducted in PubMed. Main outcomes were defined as hemangioma decreases in diameters and volume changes post-MWA. Conventional random-effect meta-analysis technique was applied to analyze the pooled data, and meta-regression model was established to explore the association among factors.Results There were nine studies with a total of 501 patients retrieved. The pooled estimate of mean differences and 95% CI of hemangioma decreases after MWA treatment in diameter and in volume change (%) were 3.009 cm and (1.856, 4.161), and 53.169% and (51.274, 55.065), respectively. The pooled estimates of liver enzyme, ALT and AST, elevation were 219.905 with 95%CI (160.860, 278.949) and 315.679 with 95%CI (226.961, 404.397), respectively. Major complications were defined as acute kidney injury (AKI), pleural effusion, diaphragmatic hernia, and jaundice that needed to be treated, and the pooled incidence was 0.017 with 95% CI of (0.006, 0.029). No mortality related to MWA was reported. Meta-regression showed ablation time was associated with pre-operative lesion size (p = .001).Conclusion MWA is effective and safe in treatment of hepatic hemangioma, and our study suggests that hemangioma size should be investigated in the future MWA pretreatment difficulty scoring system study.https://www.tandfonline.com/doi/10.1080/02656736.2022.2146214Hepatic hemangioma treatmentmicrowave ablationhepatic benign tumoreffectivenesshemangioma size |
| spellingShingle | Li Fei Xing Hongsong Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression International Journal of Hyperthermia Hepatic hemangioma treatment microwave ablation hepatic benign tumor effectiveness hemangioma size |
| title | Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression |
| title_full | Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression |
| title_fullStr | Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression |
| title_full_unstemmed | Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression |
| title_short | Effectiveness of microwave ablation for the treatment of hepatic hemangioma - meta-analysis and meta-regression |
| title_sort | effectiveness of microwave ablation for the treatment of hepatic hemangioma meta analysis and meta regression |
| topic | Hepatic hemangioma treatment microwave ablation hepatic benign tumor effectiveness hemangioma size |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2146214 |
| work_keys_str_mv | AT lifei effectivenessofmicrowaveablationforthetreatmentofhepatichemangiomametaanalysisandmetaregression AT xinghongsong effectivenessofmicrowaveablationforthetreatmentofhepatichemangiomametaanalysisandmetaregression |