Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review
Prenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal vitamin D status and offspring developmental and psychiatric outcomes in humans have been inconclusive. We aimed to sys...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/63 |
| _version_ | 1797625675588304896 |
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| author | Subina Upadhyaya Tiia Ståhlberg Sanju Silwal Bianca Arrhenius Andre Sourander |
| author_facet | Subina Upadhyaya Tiia Ståhlberg Sanju Silwal Bianca Arrhenius Andre Sourander |
| author_sort | Subina Upadhyaya |
| collection | DOAJ |
| description | Prenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal vitamin D status and offspring developmental and psychiatric outcomes in humans have been inconclusive. We aimed to systematically assess the results of previously published studies that examined the associations between maternal vitamin D levels, measured as circulating 25(OH)D levels in pregnancy or at birth, and offspring neuropsychiatric and psychiatric outcomes. Systematic searches were conducted using MEDLINE, Embase, PsychINFO and Web of Science for studies published by 10 August 2022. We included human observational studies that examined associations between prenatal or perinatal vitamin D levels and offspring neuropsychiatric and psychiatric outcomes and were published in English in peer-reviewed journals. Of the 3729 studies identified, 66 studies were screened for full texts and 29 studies published between 2003 and 2022 were included in the final review. There was a small amount of evidence for the association between prenatal vitamin D deficiency and autism spectrum disorder. When studies with larger sample sizes and stricter definitions of vitamin D deficiency were considered, positive associations were also found for attention-deficit/hyperactivity disorder and schizophrenia. Future studies with larger sample sizes, longer follow-up periods and prenatal vitamin D assessed at multiple time points are needed. |
| first_indexed | 2024-03-11T09:59:39Z |
| format | Article |
| id | doaj.art-348afd57ec17407287677bf9af5db894 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-348afd57ec17407287677bf9af5db8942023-11-16T15:28:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-012416310.3390/ijms24010063Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic ReviewSubina Upadhyaya0Tiia Ståhlberg1Sanju Silwal2Bianca Arrhenius3Andre Sourander4Research Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, FinlandResearch Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, FinlandResearch Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, FinlandResearch Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, FinlandResearch Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, FinlandPrenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal vitamin D status and offspring developmental and psychiatric outcomes in humans have been inconclusive. We aimed to systematically assess the results of previously published studies that examined the associations between maternal vitamin D levels, measured as circulating 25(OH)D levels in pregnancy or at birth, and offspring neuropsychiatric and psychiatric outcomes. Systematic searches were conducted using MEDLINE, Embase, PsychINFO and Web of Science for studies published by 10 August 2022. We included human observational studies that examined associations between prenatal or perinatal vitamin D levels and offspring neuropsychiatric and psychiatric outcomes and were published in English in peer-reviewed journals. Of the 3729 studies identified, 66 studies were screened for full texts and 29 studies published between 2003 and 2022 were included in the final review. There was a small amount of evidence for the association between prenatal vitamin D deficiency and autism spectrum disorder. When studies with larger sample sizes and stricter definitions of vitamin D deficiency were considered, positive associations were also found for attention-deficit/hyperactivity disorder and schizophrenia. Future studies with larger sample sizes, longer follow-up periods and prenatal vitamin D assessed at multiple time points are needed.https://www.mdpi.com/1422-0067/24/1/63maternalprenatalvitamin Doffspringpsychiatric outcomes25(OH)D |
| spellingShingle | Subina Upadhyaya Tiia Ståhlberg Sanju Silwal Bianca Arrhenius Andre Sourander Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review International Journal of Molecular Sciences maternal prenatal vitamin D offspring psychiatric outcomes 25(OH)D |
| title | Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review |
| title_full | Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review |
| title_fullStr | Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review |
| title_full_unstemmed | Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review |
| title_short | Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review |
| title_sort | maternal vitamin d levels during pregnancy and offspring psychiatric outcomes a systematic review |
| topic | maternal prenatal vitamin D offspring psychiatric outcomes 25(OH)D |
| url | https://www.mdpi.com/1422-0067/24/1/63 |
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