Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity
Abstract: Risk stratification of Coronavirus disease 2019 (COVID-19) patients is very important to determine patient care and prognosis. The reliable parameters include C-reactive protein (CRP), lactate dehydrogenase (LDH), and neutrophil-lymphocyte ratio (NLR). This study aimed to determine the re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Lambung Mangkurat
2023-02-01
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| Series: | Berkala Kedokteran |
| Subjects: | |
| Online Access: | https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15718 |
| _version_ | 1827352422756909056 |
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| author | Hendra Wana Nur'amin I Nyoman Suarjana Mohammad Rudiansyah Nanang Miftah Fajari Djallalluddin Djallalluddin |
| author_facet | Hendra Wana Nur'amin I Nyoman Suarjana Mohammad Rudiansyah Nanang Miftah Fajari Djallalluddin Djallalluddin |
| author_sort | Hendra Wana Nur'amin |
| collection | DOAJ |
| description | Abstract:
Risk stratification of Coronavirus disease 2019 (COVID-19) patients is very important to determine patient care and prognosis. The reliable parameters include C-reactive protein (CRP), lactate dehydrogenase (LDH), and neutrophil-lymphocyte ratio (NLR). This study aimed to determine the relationship between CRP, LDH, and NLR levels with the severity of COVID-19 patients. An observational study with a cross-sectional approach was conducted at Ulin Hospital Banjarmasin on 91 eligible subjects. A logistic regression test was conducted to determine the relationship between variables and the severity of COVID-19. The results showed that there was no significant relationship between CRP levels and the severity of COVID-19 (prevalence odds ratio (POR) 0.85, 95% confidence interval (CI 95%) 0.34-2.09, p=0.72). There was a significant difference between the mean LDH levels in severe COVID-19 compared to non-severe COVID-19 (1006 + 601.77 vs 543.5 + 480.41, p<0.001), with POR 4.23, 95% CI 95% 1.56-11.45, p=0.005; there was also a significant difference between the mean NLR values in severe COVID-19 compared to non-severe COVID-19 (9.01 + 6.32 vs 5.38 + 5.03, p=0.002) with POR of 12.21 CI 95% 3.80-39.31, p<0.001. This study showed that LDH levels and NLR values were important predictors of COVID-19 severity. |
| first_indexed | 2024-03-08T03:05:41Z |
| format | Article |
| id | doaj.art-348b460c29d44956a4e57b7a638d9bc8 |
| institution | Directory Open Access Journal |
| issn | 1412-0550 2548-5660 |
| language | English |
| last_indexed | 2024-03-08T03:05:41Z |
| publishDate | 2023-02-01 |
| publisher | Universitas Lambung Mangkurat |
| record_format | Article |
| series | Berkala Kedokteran |
| spelling | doaj.art-348b460c29d44956a4e57b7a638d9bc82024-02-13T09:27:32ZengUniversitas Lambung MangkuratBerkala Kedokteran1412-05502548-56602023-02-01191596810.20527/jbk.v19i1.157188369Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 SeverityHendra Wana Nur'amin0I Nyoman Suarjana1Mohammad Rudiansyah2Nanang Miftah Fajari3Djallalluddin Djallalluddin4Lambung Mangkurat UniversityUlin General HospitalLambung Mangkurat UniversityUlin General HospitalLambung Mangkurat UniversityAbstract: Risk stratification of Coronavirus disease 2019 (COVID-19) patients is very important to determine patient care and prognosis. The reliable parameters include C-reactive protein (CRP), lactate dehydrogenase (LDH), and neutrophil-lymphocyte ratio (NLR). This study aimed to determine the relationship between CRP, LDH, and NLR levels with the severity of COVID-19 patients. An observational study with a cross-sectional approach was conducted at Ulin Hospital Banjarmasin on 91 eligible subjects. A logistic regression test was conducted to determine the relationship between variables and the severity of COVID-19. The results showed that there was no significant relationship between CRP levels and the severity of COVID-19 (prevalence odds ratio (POR) 0.85, 95% confidence interval (CI 95%) 0.34-2.09, p=0.72). There was a significant difference between the mean LDH levels in severe COVID-19 compared to non-severe COVID-19 (1006 + 601.77 vs 543.5 + 480.41, p<0.001), with POR 4.23, 95% CI 95% 1.56-11.45, p=0.005; there was also a significant difference between the mean NLR values in severe COVID-19 compared to non-severe COVID-19 (9.01 + 6.32 vs 5.38 + 5.03, p=0.002) with POR of 12.21 CI 95% 3.80-39.31, p<0.001. This study showed that LDH levels and NLR values were important predictors of COVID-19 severity.https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15718covid-19crpldhnlr |
| spellingShingle | Hendra Wana Nur'amin I Nyoman Suarjana Mohammad Rudiansyah Nanang Miftah Fajari Djallalluddin Djallalluddin Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity Berkala Kedokteran covid-19 crp ldh nlr |
| title | Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity |
| title_full | Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity |
| title_fullStr | Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity |
| title_full_unstemmed | Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity |
| title_short | Relationship between C-Reactive Protein Levels, Lactate Dehydrogenase, and Neutrophil-to-Lymphocyte Ratio with Coronavirus Disease 2019 Severity |
| title_sort | relationship between c reactive protein levels lactate dehydrogenase and neutrophil to lymphocyte ratio with coronavirus disease 2019 severity |
| topic | covid-19 crp ldh nlr |
| url | https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15718 |
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