The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study
The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice. Aim. The main objective of this retrospective observational study was to evaluat...
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| Format: | Article |
| Language: | Russian |
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IP Habib O.N.
2020-05-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/34173/22585 |
| _version_ | 1818842108475211776 |
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| author | Elena I. Kovalenko Elena V. Artamonova Elena V. Karabina Irina I. Andreiashkina Ekaterina A. Prokof’eva Nataliia O. Popova Elena A. Gaisina Irina V. Evstigneeva Mikhail V. Shaidorov Larisa A. Zhiliaeva Dmitrii M. Ponomarenko Alfiia I. Khasanova Guzel Z. Mukhametshina Anton E. Koziakov Liudmila V. Vorotilina Anton Iu. Povyshev Elena I. Simolina Vasilii V. Marfutov Dmitrii V. Kozlov Irina R. Suslova Valentina E. Shikina Tatiana V. Karandeeva Artem O. Shepel’ Liudmila V. Kramskaia Denis A. Oskirko Olga S. Frolova |
| author_facet | Elena I. Kovalenko Elena V. Artamonova Elena V. Karabina Irina I. Andreiashkina Ekaterina A. Prokof’eva Nataliia O. Popova Elena A. Gaisina Irina V. Evstigneeva Mikhail V. Shaidorov Larisa A. Zhiliaeva Dmitrii M. Ponomarenko Alfiia I. Khasanova Guzel Z. Mukhametshina Anton E. Koziakov Liudmila V. Vorotilina Anton Iu. Povyshev Elena I. Simolina Vasilii V. Marfutov Dmitrii V. Kozlov Irina R. Suslova Valentina E. Shikina Tatiana V. Karandeeva Artem O. Shepel’ Liudmila V. Kramskaia Denis A. Oskirko Olga S. Frolova |
| author_sort | Elena I. Kovalenko |
| collection | DOAJ |
| description | The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice.
Aim. The main objective of this retrospective observational study was to evaluate the efficacy and tolerability of eribulin and trastuzumab combo in HER2+ breast cancer patients pretreated with anthracyclines and taxanes. The analysis included 60 patients who received at least 2 cycles of eribulin in combination with trastuzumab. 2 patients (3.3%) received treatment as the 1st line, as the 2nd 14 (23.3%), as the 3rd 16 (26.7%), and as the 4th and more 28 (46.7%).
Materials and methods. Complete response was achieved in 2 (3.3%) patients, partial response in 9 (15%), stable disease in 33 (55%), stabilization for more than 6 months in 11 (18.3%), disease progression was detected in 16 (26.7%) patients. The objective response rate was 18.3% in the whole group, the clinical benefit rate 36.7%.
Results. The objective response rate in the group of the luminal subtype (ER/PR+HER2+) was 26.9%, in HER2-overexpressed subtype (ER-PR-HER2+) 8.8% and 64.7%, respectively, disease progression was recorded 2.3 times more often 35.3% versus 15.5% in the luminal subtype group. The median progression-free survival in patients with HER2+ breast cancer was 4.95 months (95% confidence interval CI 3.048.29 months), in luminal subtype 6.38 months (95% CI 3.338.54 months), in non-luminal 4.44 months (95% CI 2.47.96 months); p=0.306. The treatment was well tolerated, the spectrum of adverse events corresponded to the eribulin toxicity profile.
Conclusions. The uniqueness of this study lies in the fact that on a large clinical material from the standpoint of real clinical practice, a very promising treatment regimen that is not used routinely in a number of countries has been studied, its effectiveness and satisfactory tolerance have been confirmed. |
| first_indexed | 2024-12-19T04:36:44Z |
| format | Article |
| id | doaj.art-348c12ae10644482a51e5fd30b93fd11 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-12-19T04:36:44Z |
| publishDate | 2020-05-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-348c12ae10644482a51e5fd30b93fd112022-12-21T20:35:43ZrusIP Habib O.N.Современная онкология1815-14341815-14422020-05-01221535910.26442/18151434.2020.1.20005830781The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational studyElena I. Kovalenko0https://orcid.org/0000-0003-4763-7992Elena V. Artamonova1Elena V. Karabina2https://orcid.org/0000-0002-8936-3590Irina I. Andreiashkina3Ekaterina A. Prokof’eva4Nataliia O. Popova5Elena A. Gaisina6Irina V. Evstigneeva7Mikhail V. Shaidorov8Larisa A. Zhiliaeva9Dmitrii M. Ponomarenko10Alfiia I. Khasanova11Guzel Z. Mukhametshina12Anton E. Koziakov13Liudmila V. Vorotilina14Anton Iu. Povyshev15Elena I. Simolina16Vasilii V. Marfutov17Dmitrii V. Kozlov18Irina R. Suslova19Valentina E. Shikina20Tatiana V. Karandeeva21Artem O. Shepel’22Liudmila V. Kramskaia23Denis A. Oskirko24Olga S. Frolova25Blokhin National Medical Research Center of OncologyBlokhin National Medical Research Center of OncologyTula Regional Oncologic DispensaryLoginov Moscow Clinical Scientific Practical CenterCity Clinic №60Tomsk National Research Medical CenterMultidisciplinary Clinical Medical Center “Medical City”Tver Regional Clinical Oncology CenterTogliatti City Clinical Hospital №5Kursk Regional Clinical Oncology CenterRegional Oncology CenterRepublican Clinical Oncology CenterRepublican Clinical Oncology CenterNovosibirsk Regional Clinical Oncology CenterClinical Oncology CenterDistrict Clinical HospitalTomsk National Research Medical CenterLoginov Moscow Clinical Scientific Practical CenterDiagnostic Clinical Center №1, branch №5Oncology Center №4Federal Research Center for Specialized Types of Medical Assistance and Medical TechnologiesPletnev City Clinical HospitalPletnev City Clinical HospitalPletnev City Clinical HospitalPletnev City Clinical HospitalSaint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology)The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice. Aim. The main objective of this retrospective observational study was to evaluate the efficacy and tolerability of eribulin and trastuzumab combo in HER2+ breast cancer patients pretreated with anthracyclines and taxanes. The analysis included 60 patients who received at least 2 cycles of eribulin in combination with trastuzumab. 2 patients (3.3%) received treatment as the 1st line, as the 2nd 14 (23.3%), as the 3rd 16 (26.7%), and as the 4th and more 28 (46.7%). Materials and methods. Complete response was achieved in 2 (3.3%) patients, partial response in 9 (15%), stable disease in 33 (55%), stabilization for more than 6 months in 11 (18.3%), disease progression was detected in 16 (26.7%) patients. The objective response rate was 18.3% in the whole group, the clinical benefit rate 36.7%. Results. The objective response rate in the group of the luminal subtype (ER/PR+HER2+) was 26.9%, in HER2-overexpressed subtype (ER-PR-HER2+) 8.8% and 64.7%, respectively, disease progression was recorded 2.3 times more often 35.3% versus 15.5% in the luminal subtype group. The median progression-free survival in patients with HER2+ breast cancer was 4.95 months (95% confidence interval CI 3.048.29 months), in luminal subtype 6.38 months (95% CI 3.338.54 months), in non-luminal 4.44 months (95% CI 2.47.96 months); p=0.306. The treatment was well tolerated, the spectrum of adverse events corresponded to the eribulin toxicity profile. Conclusions. The uniqueness of this study lies in the fact that on a large clinical material from the standpoint of real clinical practice, a very promising treatment regimen that is not used routinely in a number of countries has been studied, its effectiveness and satisfactory tolerance have been confirmed.https://modernonco.orscience.ru/1815-1434/article/viewFile/34173/22585breast cancereribulinefficacytolerance |
| spellingShingle | Elena I. Kovalenko Elena V. Artamonova Elena V. Karabina Irina I. Andreiashkina Ekaterina A. Prokof’eva Nataliia O. Popova Elena A. Gaisina Irina V. Evstigneeva Mikhail V. Shaidorov Larisa A. Zhiliaeva Dmitrii M. Ponomarenko Alfiia I. Khasanova Guzel Z. Mukhametshina Anton E. Koziakov Liudmila V. Vorotilina Anton Iu. Povyshev Elena I. Simolina Vasilii V. Marfutov Dmitrii V. Kozlov Irina R. Suslova Valentina E. Shikina Tatiana V. Karandeeva Artem O. Shepel’ Liudmila V. Kramskaia Denis A. Oskirko Olga S. Frolova The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study Современная онкология breast cancer eribulin efficacy tolerance |
| title | The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study |
| title_full | The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study |
| title_fullStr | The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study |
| title_full_unstemmed | The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study |
| title_short | The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study |
| title_sort | efficacy of the combination of eribulin and trastuzumab in advanced her2 positive breast cancer the results of russian observational study |
| topic | breast cancer eribulin efficacy tolerance |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/34173/22585 |
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