Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a simil...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2014-11-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948&lng=en&tlng=en |
| _version_ | 1797756762667876352 |
|---|---|
| author | Omaira Vera Lizcano Sarah Stela Resende Yonne F Chehuan Marcus VG Lacerda Cristiana FA Brito Mariano G Zalis |
| author_facet | Omaira Vera Lizcano Sarah Stela Resende Yonne F Chehuan Marcus VG Lacerda Cristiana FA Brito Mariano G Zalis |
| author_sort | Omaira Vera Lizcano |
| collection | DOAJ |
| description | The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world. |
| first_indexed | 2024-03-12T18:06:14Z |
| format | Article |
| id | doaj.art-348d58d6a5e34306a564bd559656ce31 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:06:14Z |
| publishDate | 2014-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-348d58d6a5e34306a564bd559656ce312023-08-02T09:28:21ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602014-11-01109794895110.1590/0074-0276140241S0074-02762014000700948Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian AmazonOmaira Vera LizcanoSarah Stela ResendeYonne F ChehuanMarcus VG LacerdaCristiana FA BritoMariano G ZalisThe molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948&lng=en&tlng=enPlasmodium vivaxchloroquineresistance |
| spellingShingle | Omaira Vera Lizcano Sarah Stela Resende Yonne F Chehuan Marcus VG Lacerda Cristiana FA Brito Mariano G Zalis Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon Memorias do Instituto Oswaldo Cruz Plasmodium vivax chloroquine resistance |
| title | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon |
| title_full | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon |
| title_fullStr | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon |
| title_full_unstemmed | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon |
| title_short | Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon |
| title_sort | genetic diversity of chloroquine resistant plasmodium vivax parasites from the western brazilian amazon |
| topic | Plasmodium vivax chloroquine resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948&lng=en&tlng=en |
| work_keys_str_mv | AT omairaveralizcano geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon AT sarahstelaresende geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon AT yonnefchehuan geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon AT marcusvglacerda geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon AT cristianafabrito geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon AT marianogzalis geneticdiversityofchloroquineresistantplasmodiumvivaxparasitesfromthewesternbrazilianamazon |