Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization.
<h4>Objective</h4>To reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach.<h4>Methods</h4>GWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the U...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290530&type=printable |
| _version_ | 1797662112658489344 |
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| author | Weiwei Ma Xiaohong Zhou Xin Huang Yong Xiong |
| author_facet | Weiwei Ma Xiaohong Zhou Xin Huang Yong Xiong |
| author_sort | Weiwei Ma |
| collection | DOAJ |
| description | <h4>Objective</h4>To reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach.<h4>Methods</h4>GWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the University of Bristol.Univariable, multivariable, and mediated MR analyses were used to explore the relationship between BMI, type 2 diabetes, and BMD. beta(β) values were given, and three methods, including inverse variance weighting, MR-Egger regression, and weighted median, were used in this analysis.<h4>Results</h4>Univariable mendelian randomization (UVMR) results showed that BMI and type 2 diabetes were positively associated with BMD. However, the association between BMI and BMD was insignificant in the multivariable Mendelian randomization (MVMR) analysis, while that between type 2 diabetes and BMD remained significant. Mediated MR analysis indicated that type 2 diabetes mediated the regulation of BMD by BMI.<h4>Conclusion</h4>This study provides evidence supporting a positive causal association between BMI, type 2 diabetes, and BMD. Type 2 diabetes acts as a mediator in the regulation of BMD by BMI, indicating that both BMI and type 2 diabetes exert a protective influence on BMD. |
| first_indexed | 2024-03-11T18:55:22Z |
| format | Article |
| id | doaj.art-348f6f43c7bb4a78988fc975fc17d05b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T18:55:22Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-348f6f43c7bb4a78988fc975fc17d05b2023-10-11T05:32:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029053010.1371/journal.pone.0290530Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization.Weiwei MaXiaohong ZhouXin HuangYong Xiong<h4>Objective</h4>To reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach.<h4>Methods</h4>GWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the University of Bristol.Univariable, multivariable, and mediated MR analyses were used to explore the relationship between BMI, type 2 diabetes, and BMD. beta(β) values were given, and three methods, including inverse variance weighting, MR-Egger regression, and weighted median, were used in this analysis.<h4>Results</h4>Univariable mendelian randomization (UVMR) results showed that BMI and type 2 diabetes were positively associated with BMD. However, the association between BMI and BMD was insignificant in the multivariable Mendelian randomization (MVMR) analysis, while that between type 2 diabetes and BMD remained significant. Mediated MR analysis indicated that type 2 diabetes mediated the regulation of BMD by BMI.<h4>Conclusion</h4>This study provides evidence supporting a positive causal association between BMI, type 2 diabetes, and BMD. Type 2 diabetes acts as a mediator in the regulation of BMD by BMI, indicating that both BMI and type 2 diabetes exert a protective influence on BMD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290530&type=printable |
| spellingShingle | Weiwei Ma Xiaohong Zhou Xin Huang Yong Xiong Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. PLoS ONE |
| title | Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. |
| title_full | Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. |
| title_fullStr | Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. |
| title_full_unstemmed | Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. |
| title_short | Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization. |
| title_sort | causal relationship between body mass index type 2 diabetes and bone mineral density mendelian randomization |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290530&type=printable |
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