Development of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice

Development of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice

Head and neck squamous cell carcinomas (HNSCC) caused by infections with high-risk human papillomaviruses (HPV) are responsible for an increasing number of head and neck cancers, particularly in the oropharynx. Despite the significant biological differences between HPV-driven and HPV-negative HNSCC,...

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Bibliographic Details
Main Authors: Christoph Schifflers, Samantha Zottnick, Jonas D. Förster, Sebastian Kruse, Ruwen Yang, Hendrik Wiethoff, Matthias Bozza, Karin Hoppe-Seyler, Mathias Heikenwälder, Richard P. Harbottle, Carine Michiels, Angelika B. Riemer
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pathogens
Subjects:
head and neck squamous cell carcinoma
human papillomavirus
orthotopic tumor model
Online Access:https://www.mdpi.com/2076-0817/12/2/188

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