Ultrasound‐microbubble cavitation facilitates adeno‐associated virus mediated cochlear gene transfection across the round‐window membrane

Ultrasound‐microbubble cavitation facilitates adeno‐associated virus mediated cochlear gene transfection across the round‐window membrane

Abstract The round window of the cochlea provides an ideal route for delivering medicines and gene therapy reagents that can cross the round window membrane (RWM) into the inner ear. Recombinant adeno‐associated viruses (rAAVs) have several advantages and are recommended as viral vectors for gene tr...

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Bibliographic Details
Main Authors: Zhen Zhang, Zhengnong Chen, Liqiang Fan, Thomas Landry, Jeremy Brown, Zhiping Yu, Shankai Yin, Jian Wang
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Bioengineering & Translational Medicine
Subjects:
cochlea
cochlear gene therapy
gene delivery
Guinea pigs
recombinant adeno‐associated virus
round window membrane
Online Access:https://doi.org/10.1002/btm2.10189

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