Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study
We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. We studied 2,756 postmenopausal subjects out of ≥10,000 records from the ROIS registry in the frame of the PROF Project, a population study carried out in Salento (Taranto, Brin...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-09-01
|
| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1401200309 |
| _version_ | 1818290352007675904 |
|---|---|
| author | C. Neglia A. Argentiero G. Chitano N. Agnello L. Giolli G. Di Tanna D. Paladini A. Amati A. Marsico V. Caiaffa P. Conte G. La Selva S. Crafa G. Colì R. Ciccarese A. Vigilanza C. Distante D. Argentiero V. Pantile M. Benvenuto T. Di Renzo A. Reale R. Coppola A. Distante A. Colao C. Di Somma A. Migliore R. Auriemma P. Piscitelli |
| author_facet | C. Neglia A. Argentiero G. Chitano N. Agnello L. Giolli G. Di Tanna D. Paladini A. Amati A. Marsico V. Caiaffa P. Conte G. La Selva S. Crafa G. Colì R. Ciccarese A. Vigilanza C. Distante D. Argentiero V. Pantile M. Benvenuto T. Di Renzo A. Reale R. Coppola A. Distante A. Colao C. Di Somma A. Migliore R. Auriemma P. Piscitelli |
| author_sort | C. Neglia |
| collection | DOAJ |
| description | We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. We studied 2,756 postmenopausal subjects out of ≥10,000 records from the ROIS registry in the frame of the PROF Project, a population study carried out in Salento (Taranto, Brindisi, Lecce) from 2009 to 2012. All subjects were assessed by phalangeal Quantitative Ultrasound (QUS) to evaluate their bone mineralization (assessed by Amplitude Dependent Speed of Sound, AD-SoS) and the association between demineralization and the presence of other conditions or risk factors. Mean age was 64±9.5 years and mean BMI was 28.7±3.5 Kg/m 2 . Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (P<0.001). By using multivariate logistic regression analysis, we observed significant values of Odds Ratios of osteoporosis (adjusted for age, physical activity and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (CI: 1,05–1,83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher Odds Ratios of osteoporosis was found for increasing values of BMI. The percent change in the odds of vertebral fractures per single SD decrease of AD-SoS was 47% (P<0.001). Diabetes and obesity in postmenopausal women are likely to represent independent risk factors for osteoporosis. Phalangeal QUS showed a good power of predictivity in identifying subjects with vertebral fractures. |
| first_indexed | 2024-12-13T02:26:48Z |
| format | Article |
| id | doaj.art-3491f9910c69468285c51e880b430f82 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-13T02:26:48Z |
| publishDate | 2014-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-3491f9910c69468285c51e880b430f822022-12-22T00:02:36ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2014-09-011210.1177/1721727X1401200309Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population StudyC. Neglia0A. Argentiero1G. Chitano2N. Agnello3L. Giolli4G. Di Tanna5D. Paladini6A. Amati7A. Marsico8V. Caiaffa9P. Conte10G. La Selva11S. Crafa12G. Colì13R. Ciccarese14A. Vigilanza15C. Distante16D. Argentiero17V. Pantile18M. Benvenuto19T. Di Renzo20A. Reale21R. Coppola22A. Distante23A. Colao24C. Di Somma25A. Migliore26R. Auriemma27P. Piscitelli28 Department of Biological and Environmental Science and Technology (Di.S.T.E.B.A), University of Salento, Lecce, Italy Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy E-Campus University, Novedrate, Italy Sapienza, University of Rome, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy Local Health Authority, ASL Taranto Taranto, Italy Local Health Authority, ASL Taranto Taranto, Italy Local Health Authority, ASL Taranto Taranto, Italy Local Health Authority, ASL Taranto Taranto, Italy Local Health Authority, ASL Brindisi, Brindisi, Italy Local Health Authority, ASL Taranto Taranto, Italy Local Health Authority, ASL Lecce, Gallipoli Hospital, Gallipoli, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy CNR ISA, Avellino, Italy CNR ISA, Avellino, Italy CNR ISA, Avellino, Italy ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi, Italy Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy IRCCS SDN Foundation, Naples, Italy Fatebenefratelli St. Peter's Hospital- Department of Rheumatology, Rome, Italy Coleman Ltd, Naples, Italy Coleman Ltd, Naples, ItalyWe aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. We studied 2,756 postmenopausal subjects out of ≥10,000 records from the ROIS registry in the frame of the PROF Project, a population study carried out in Salento (Taranto, Brindisi, Lecce) from 2009 to 2012. All subjects were assessed by phalangeal Quantitative Ultrasound (QUS) to evaluate their bone mineralization (assessed by Amplitude Dependent Speed of Sound, AD-SoS) and the association between demineralization and the presence of other conditions or risk factors. Mean age was 64±9.5 years and mean BMI was 28.7±3.5 Kg/m 2 . Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (P<0.001). By using multivariate logistic regression analysis, we observed significant values of Odds Ratios of osteoporosis (adjusted for age, physical activity and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (CI: 1,05–1,83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher Odds Ratios of osteoporosis was found for increasing values of BMI. The percent change in the odds of vertebral fractures per single SD decrease of AD-SoS was 47% (P<0.001). Diabetes and obesity in postmenopausal women are likely to represent independent risk factors for osteoporosis. Phalangeal QUS showed a good power of predictivity in identifying subjects with vertebral fractures.https://doi.org/10.1177/1721727X1401200309 |
| spellingShingle | C. Neglia A. Argentiero G. Chitano N. Agnello L. Giolli G. Di Tanna D. Paladini A. Amati A. Marsico V. Caiaffa P. Conte G. La Selva S. Crafa G. Colì R. Ciccarese A. Vigilanza C. Distante D. Argentiero V. Pantile M. Benvenuto T. Di Renzo A. Reale R. Coppola A. Distante A. Colao C. Di Somma A. Migliore R. Auriemma P. Piscitelli Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study European Journal of Inflammation |
| title | Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study |
| title_full | Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study |
| title_fullStr | Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study |
| title_full_unstemmed | Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study |
| title_short | Diabetes and Obesity as Independent Risk Factors for Osteoporosis in Postmenopausal Women: A Population Study |
| title_sort | diabetes and obesity as independent risk factors for osteoporosis in postmenopausal women a population study |
| url | https://doi.org/10.1177/1721727X1401200309 |
| work_keys_str_mv | AT cneglia diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT aargentiero diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT gchitano diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT nagnello diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT lgiolli diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT gditanna diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT dpaladini diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT aamati diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT amarsico diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT vcaiaffa diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT pconte diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT glaselva diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT scrafa diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT gcoli diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT rciccarese diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT avigilanza diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT cdistante diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT dargentiero diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT vpantile diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT mbenvenuto diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT tdirenzo diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT areale diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT rcoppola diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT adistante diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT acolao diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT cdisomma diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT amigliore diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT rauriemma diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy AT ppiscitelli diabetesandobesityasindependentriskfactorsforosteoporosisinpostmenopausalwomenapopulationstudy |