Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study
<p>Abstract</p> <p>A comprehensive revision of the Global Burden of Disease (GBD) study is expected to be completed in 2012. This study utilizes a broad range of improved methods for assessing burden, including closer attention to empirically derived estimates of disability. The ai...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Population Health Metrics |
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| Online Access: | http://www.pophealthmetrics.com/content/10/1/16 |
| _version_ | 1811252804460740608 |
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| author | Ferrari Alize J Saha Sukanta McGrath John J Norman Rosana Baxter Amanda J Vos Theo Whiteford Harvey A |
| author_facet | Ferrari Alize J Saha Sukanta McGrath John J Norman Rosana Baxter Amanda J Vos Theo Whiteford Harvey A |
| author_sort | Ferrari Alize J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>A comprehensive revision of the Global Burden of Disease (GBD) study is expected to be completed in 2012. This study utilizes a broad range of improved methods for assessing burden, including closer attention to empirically derived estimates of disability. The aim of this paper is to describe how GBD health states were derived for schizophrenia and bipolar disorder. These will be used in deriving health state-specific disability estimates. A literature review was first conducted to settle on a parsimonious set of health states for schizophrenia and bipolar disorder. A second review was conducted to investigate the proportion of schizophrenia and bipolar disorder cases experiencing these health states. These were pooled using a quality-effects model to estimate the overall proportion of cases in each state. The two schizophrenia health states were acute (predominantly positive symptoms) and residual (predominantly negative symptoms). The three bipolar disorder health states were depressive, manic, and residual. Based on estimates from six studies, 63% (38%-82%) of schizophrenia cases were in an acute state and 37% (18%-62%) were in a residual state. Another six studies were identified from which 23% (10%-39%) of bipolar disorder cases were in a manic state, 27% (11%-47%) were in a depressive state, and 50% (30%-70%) were in a residual state. This literature review revealed salient gaps in the literature that need to be addressed in future research. The pooled estimates are indicative only and more data are required to generate more definitive estimates. That said, rather than deriving burden estimates that fail to capture the changes in disability within schizophrenia and bipolar disorder, the derived proportions and their wide uncertainty intervals will be used in deriving disability estimates.</p> |
| first_indexed | 2024-04-12T16:40:12Z |
| format | Article |
| id | doaj.art-3492181dcdfe4022a3dd524b380d7e11 |
| institution | Directory Open Access Journal |
| issn | 1478-7954 |
| language | English |
| last_indexed | 2024-04-12T16:40:12Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Population Health Metrics |
| spelling | doaj.art-3492181dcdfe4022a3dd524b380d7e112022-12-22T03:24:48ZengBMCPopulation Health Metrics1478-79542012-08-011011610.1186/1478-7954-10-16Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 StudyFerrari Alize JSaha SukantaMcGrath John JNorman RosanaBaxter Amanda JVos TheoWhiteford Harvey A<p>Abstract</p> <p>A comprehensive revision of the Global Burden of Disease (GBD) study is expected to be completed in 2012. This study utilizes a broad range of improved methods for assessing burden, including closer attention to empirically derived estimates of disability. The aim of this paper is to describe how GBD health states were derived for schizophrenia and bipolar disorder. These will be used in deriving health state-specific disability estimates. A literature review was first conducted to settle on a parsimonious set of health states for schizophrenia and bipolar disorder. A second review was conducted to investigate the proportion of schizophrenia and bipolar disorder cases experiencing these health states. These were pooled using a quality-effects model to estimate the overall proportion of cases in each state. The two schizophrenia health states were acute (predominantly positive symptoms) and residual (predominantly negative symptoms). The three bipolar disorder health states were depressive, manic, and residual. Based on estimates from six studies, 63% (38%-82%) of schizophrenia cases were in an acute state and 37% (18%-62%) were in a residual state. Another six studies were identified from which 23% (10%-39%) of bipolar disorder cases were in a manic state, 27% (11%-47%) were in a depressive state, and 50% (30%-70%) were in a residual state. This literature review revealed salient gaps in the literature that need to be addressed in future research. The pooled estimates are indicative only and more data are required to generate more definitive estimates. That said, rather than deriving burden estimates that fail to capture the changes in disability within schizophrenia and bipolar disorder, the derived proportions and their wide uncertainty intervals will be used in deriving disability estimates.</p>http://www.pophealthmetrics.com/content/10/1/16Global Burden of DiseaseHealth StatesSchizophreniaBipolar Disorder |
| spellingShingle | Ferrari Alize J Saha Sukanta McGrath John J Norman Rosana Baxter Amanda J Vos Theo Whiteford Harvey A Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study Population Health Metrics Global Burden of Disease Health States Schizophrenia Bipolar Disorder |
| title | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study |
| title_full | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study |
| title_fullStr | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study |
| title_full_unstemmed | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study |
| title_short | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study |
| title_sort | health states for schizophrenia and bipolar disorder within the global burden of disease 2010 study |
| topic | Global Burden of Disease Health States Schizophrenia Bipolar Disorder |
| url | http://www.pophealthmetrics.com/content/10/1/16 |
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