Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells
Mesenchymal Stromal Cells are hard to expand whilst retaining immunomodulatory properties due to spontaneous differentiation and ageing in culture. Here, the authors describe a mechanotransductive link between metabolism and functional activity and identify bioactive metabolites to expand functional...
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Bibliographic Details
| Main Authors: |
Ewan A. Ross,
Lesley-Anne Turner,
Hannah Donnelly,
Anwer Saeed,
Monica P. Tsimbouri,
Karl V. Burgess,
Gavin Blackburn,
Vineetha Jayawarna,
Yinbo Xiao,
Mariana A. G. Oliva,
Jennifer Willis,
Jaspreet Bansal,
Paul Reynolds,
Julia A. Wells,
Joanne Mountford,
Massimo Vassalli,
Nikolaj Gadegaard,
Richard O. C. Oreffo,
Manuel Salmeron-Sanchez,
Matthew J. Dalby |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-36293-7
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