AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS
Objectives: T-cell Brazil project started in April 2017 focusing to collecting epidemiological and clinical data from the most frequent subtypes of PTCL, as an ambispective study collected diagnosis data from January 2015 to December 2022. Our goals were to obtain the frequency of subtypes and the c...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923008222 |
| _version_ | 1797654959000387584 |
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| author | CS Chiattone E Miranda SS Medina RLR Baptista J Pereira SAB Brasil JV Tavares KZ Cecyn FL Nogueira M Bellosso DFC Farias D Borducchi NS Castro S Nabhan PPG Rakde CCG Macedo CC Vilarim M Dias E Negreiros VLP Figueiredo DV Clé R Schaffel RD Gaiolla S Schusterschitz T Fischer GF Silva Y Gonzaga N Zing AD Cunha-Jr JTD Souto-Filho S Mo EFO Ribeiro FB Duarte RR Sousa MAL Matedi MD Pont N Hamerschlak G Perini YS Rabelo ND Bueno P Cury A Hallack-Neto MT Delamain M Federico CA Souza |
| author_facet | CS Chiattone E Miranda SS Medina RLR Baptista J Pereira SAB Brasil JV Tavares KZ Cecyn FL Nogueira M Bellosso DFC Farias D Borducchi NS Castro S Nabhan PPG Rakde CCG Macedo CC Vilarim M Dias E Negreiros VLP Figueiredo DV Clé R Schaffel RD Gaiolla S Schusterschitz T Fischer GF Silva Y Gonzaga N Zing AD Cunha-Jr JTD Souto-Filho S Mo EFO Ribeiro FB Duarte RR Sousa MAL Matedi MD Pont N Hamerschlak G Perini YS Rabelo ND Bueno P Cury A Hallack-Neto MT Delamain M Federico CA Souza |
| author_sort | CS Chiattone |
| collection | DOAJ |
| description | Objectives: T-cell Brazil project started in April 2017 focusing to collecting epidemiological and clinical data from the most frequent subtypes of PTCL, as an ambispective study collected diagnosis data from January 2015 to December 2022. Our goals were to obtain the frequency of subtypes and the clinical and biology characteristic from five Brazilian regions; besides to have a routine pathological revision and to evaluate the Overall Survival (OS), Progression-Free Survival (PFS) in 5 years of follow-up. Method: After 39 centers were approved by their Ethical Committee, they registered their cases using the REDcap Platform by Vanderbilt, being 63% public centers. Here, It was just analyzed a Prospective Cohort (PC), with diagnosis date from April 2017 to December 2022, a total of 461 cases. Descriptive analyses, Kaplan-Meier method, Log-Rank test to compare groups and Cox Regression to identify risk factor for OS using IBM-SPSS software v.24. Results: The median age was 52 years (18-92); 58% male; Almost 72% had advanced stages, 25% ECOG ≥ 2; the distribution of main subtypes was: 30% PTCL-NOS; 18% ALCL, ALK-; 14% ATL; 13% ENKTL-NT; 10.5% AITL; 5% ALCL, ALK+; 9.5% others. A median of follow up of 22 months (0-73), 55% pts were alive and 24-month PFS and OS were 36% and 49%, respectively. OS by main subtypes was 69% ALCL, ALK+; 61% ALCL, ALK; 50% PTCL-NOS; 44% ENKTL-NT; 41% AITL; 27% ATL. Cox regression showed ATL (HR 1.6, p = 0.008), ECOG ≥ 2 (HR 1.86, p < 0.0001) and Ann Arbor Stage III-IV (HR 2.06, p < 0.0001) as bad prognosis for OS; whereas for PFS were ATL (HR 1.9, p < 0.0001); ECOG≥ 2 (HR 1.53, p = 0.002); Ann Arbor Stage III-IV (HR 1.75, p = 0.001) and B symptoms (HR 1.36, p = 0.02). Discussion: PTCL make up approximately 10-15% of lymphoid malignancies and its frequency varies geographically. In Brazil, mainly due to its vast dimension, data collection has limitations and is subject to bias. This is the first experience cover all over the country, focusing also an educational and of interchanging experience network among the multidisciplinary health team in Brazil. Conclusions: Our initial target of 500 pts exceeded, hence the number of prospective cohort is getting close, because we are in a consistency data phase and probably more cases will be available after that. So, it is possible to make analyzes with PC. ATL and ENKTL-NT subtype presented more frequent of all, different of the Occidental countries, but similar with recent data from American Latin. |
| first_indexed | 2024-03-11T17:07:08Z |
| format | Article |
| id | doaj.art-34934cf181a7482799c281eb9e495689 |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-11T17:07:08Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-34934cf181a7482799c281eb9e4956892023-10-20T06:42:30ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-10-0145S332S333AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSISCS Chiattone0E Miranda1SS Medina2RLR Baptista3J Pereira4SAB Brasil5JV Tavares6KZ Cecyn7FL Nogueira8M Bellosso9DFC Farias10D Borducchi11NS Castro12S Nabhan13PPG Rakde14CCG Macedo15CC Vilarim16M Dias17E Negreiros18VLP Figueiredo19DV Clé20R Schaffel21RD Gaiolla22S Schusterschitz23T Fischer24GF Silva25Y Gonzaga26N Zing27AD Cunha-Jr28JTD Souto-Filho29S Mo30EFO Ribeiro31FB Duarte32RR Sousa33MAL Matedi34MD Pont35N Hamerschlak36G Perini37YS Rabelo38ND Bueno39P Cury40A Hallack-Neto41MT Delamain42M Federico43CA Souza44Hospital Samaritano, São Paulo, Brazil; Faculdade de Ciências Médicas da Santa Casa São Paulo (FCMSCSP), São Paulo, BrazilCentro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, BrazilCentro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, BrazilUniversidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, BrazilFaculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, BrazilFaculdade de Ciências Médicas da Santa Casa São Paulo (FCMSCSP), São Paulo, BrazilHospital Ophir Loyola (HOL), Belém, BrazilHospital Ophir Loyola (HOL), Belém, BrazilHospital Luxemburgo (HL), Instituto Mario Penna, Belo Horizonte, BrazilHemoMed, Instituto de Ensino e Pesquisa (IEP), São Paulo, BrazilA Beneficência Portuguesa de São Paulo (BP), São Paulo, BrazilFaculdade de Medicina do ABC (FMABC), Santo André, BrazilHospital de Câncer de Barretos, Hospital de Amor de Barretos, Barretos, BrazilUniversidade Federal do Paraná (UFPR), Curitiba, BrazilCasa de Saúde Santa Marcelina, São Paulo, BrazilInstituto de Ensino, Pesquisa e Inovação, Liga Contra o Câncer (CECAN), Natal, BrazilInstituto de Ensino, Pesquisa e Inovação, Liga Contra o Câncer (CECAN), Natal, BrazilUniversidade Federal da Bahia (UFBA), Salvador, BrazilHospital de Amor Amazônia, Fundação Pio XII, Porto Velho, BrazilHospital do Servidor Público do Estado de São Paulo (HSPE), Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, BrazilFaculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, BrazilHospital Universitário Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, BrazilFaculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilAC Camargo Câncer Center, São Paulo, BrazilHospital Aldenora Bello, São Luís, BrazilInstituto Nacional de Câncer (INCA), BrazilPrevent Senior, São Paulo, BrazilHematology and Oncology Clinics, Cancer Hospital of Cascavel, União Oeste Paranaense de Estudos e Combate ao Câncer (UOPECCAN), Cascavel, BrazilFaculdade de Medicina de Campos (FMC), Campos dos Goytacazes, BrazilHospital Samaritano, São Paulo, BrazilHospital Santa Lúcia, Brasília, BrazilHospital Universitário Walter Cantídio (HUWC), Universidade Federal do Ceará (UFC), Fortaleza, BrazilHospital Universitário Walter Cantídio (HUWC), Universidade Federal do Ceará (UFC), Fortaleza, BrazilSanta Casa de Belo Horizonte, Belo Horizonte, BrazilCentro de Pesquisas Oncológicas de Santa Catarina (CEPON), Florianópolis, BrazilHospital Israelita Albert Einstein (HIAE), São Paulo, BrazilHospital Paulistano, Oncologia Américas, São Paulo, BrazilUniversidade Federal de Goiás (UFG), Goiânia, BrazilFrad Clínica Médica, Santo André, BrazilClínica São Germano, São Paulo, BrazilUniversidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, BrasilFaculdade Ciências Médicas de Minas Gerais (FCM-MG), Belo Horizonte, BrazilUniversity of Modena and Reggio Emília, ItalyCentro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, BrazilObjectives: T-cell Brazil project started in April 2017 focusing to collecting epidemiological and clinical data from the most frequent subtypes of PTCL, as an ambispective study collected diagnosis data from January 2015 to December 2022. Our goals were to obtain the frequency of subtypes and the clinical and biology characteristic from five Brazilian regions; besides to have a routine pathological revision and to evaluate the Overall Survival (OS), Progression-Free Survival (PFS) in 5 years of follow-up. Method: After 39 centers were approved by their Ethical Committee, they registered their cases using the REDcap Platform by Vanderbilt, being 63% public centers. Here, It was just analyzed a Prospective Cohort (PC), with diagnosis date from April 2017 to December 2022, a total of 461 cases. Descriptive analyses, Kaplan-Meier method, Log-Rank test to compare groups and Cox Regression to identify risk factor for OS using IBM-SPSS software v.24. Results: The median age was 52 years (18-92); 58% male; Almost 72% had advanced stages, 25% ECOG ≥ 2; the distribution of main subtypes was: 30% PTCL-NOS; 18% ALCL, ALK-; 14% ATL; 13% ENKTL-NT; 10.5% AITL; 5% ALCL, ALK+; 9.5% others. A median of follow up of 22 months (0-73), 55% pts were alive and 24-month PFS and OS were 36% and 49%, respectively. OS by main subtypes was 69% ALCL, ALK+; 61% ALCL, ALK; 50% PTCL-NOS; 44% ENKTL-NT; 41% AITL; 27% ATL. Cox regression showed ATL (HR 1.6, p = 0.008), ECOG ≥ 2 (HR 1.86, p < 0.0001) and Ann Arbor Stage III-IV (HR 2.06, p < 0.0001) as bad prognosis for OS; whereas for PFS were ATL (HR 1.9, p < 0.0001); ECOG≥ 2 (HR 1.53, p = 0.002); Ann Arbor Stage III-IV (HR 1.75, p = 0.001) and B symptoms (HR 1.36, p = 0.02). Discussion: PTCL make up approximately 10-15% of lymphoid malignancies and its frequency varies geographically. In Brazil, mainly due to its vast dimension, data collection has limitations and is subject to bias. This is the first experience cover all over the country, focusing also an educational and of interchanging experience network among the multidisciplinary health team in Brazil. Conclusions: Our initial target of 500 pts exceeded, hence the number of prospective cohort is getting close, because we are in a consistency data phase and probably more cases will be available after that. So, it is possible to make analyzes with PC. ATL and ENKTL-NT subtype presented more frequent of all, different of the Occidental countries, but similar with recent data from American Latin.http://www.sciencedirect.com/science/article/pii/S2531137923008222 |
| spellingShingle | CS Chiattone E Miranda SS Medina RLR Baptista J Pereira SAB Brasil JV Tavares KZ Cecyn FL Nogueira M Bellosso DFC Farias D Borducchi NS Castro S Nabhan PPG Rakde CCG Macedo CC Vilarim M Dias E Negreiros VLP Figueiredo DV Clé R Schaffel RD Gaiolla S Schusterschitz T Fischer GF Silva Y Gonzaga N Zing AD Cunha-Jr JTD Souto-Filho S Mo EFO Ribeiro FB Duarte RR Sousa MAL Matedi MD Pont N Hamerschlak G Perini YS Rabelo ND Bueno P Cury A Hallack-Neto MT Delamain M Federico CA Souza AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS Hematology, Transfusion and Cell Therapy |
| title | AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS |
| title_full | AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS |
| title_fullStr | AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS |
| title_full_unstemmed | AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS |
| title_short | AN UPDATED OF PERIPHERAL T-CELL LYMPHOMA PATIENTS REGISTRY OF T-CELL BRAZIL PROJECT: A PROSPECTIVE COHORT ANALYSIS |
| title_sort | updated of peripheral t cell lymphoma patients registry of t cell brazil project a prospective cohort analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923008222 |
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