Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone

Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone

Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear. In this study, we aimed to clarify regulatory mechan...

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Bibliographic Details
Main Authors: Hiroki Hagizawa, Saeko Koyamatsu, Seiji Okada, Takashi Kaito, Noriyuki Tsumaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nucleus pulposus cells
chondrocytes
single-cell RNA sequencing
hedgehog
HIF-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1151947/full

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