Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma
IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer initiation and progressi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.920652/full |
| _version_ | 1818553076377714688 |
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| author | Qingqing Dai Qingqing Dai Quratul Ain Michael Rooney Fei Song Alexander Zipprich |
| author_facet | Qingqing Dai Qingqing Dai Quratul Ain Michael Rooney Fei Song Alexander Zipprich |
| author_sort | Qingqing Dai |
| collection | DOAJ |
| description | IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer initiation and progression has received increasing attention in recent years, especially in hepatocellular carcinoma (HCC), where the aberrant expression of IQGAPs is closely related to patient prognosis. IQGAP1 and 3 are upregulated and are considered oncogenes in HCC, while IQGAP2 is downregulated and functions as a tumor suppressor. This review details the three IQGAP isoforms and their respective structures. The expression and role of each protein in different liver diseases and mainly in HCC, as well as the underlying mechanisms, are also presented. This review also provides a reference for further studies on IQGAPs in HCC. |
| first_indexed | 2024-12-12T09:21:19Z |
| format | Article |
| id | doaj.art-34971f18dd2344f5aadd930af506b114 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T09:21:19Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-34971f18dd2344f5aadd930af506b1142022-12-22T00:29:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.920652920652Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular CarcinomaQingqing Dai0Qingqing Dai1Quratul Ain2Michael Rooney3Fei Song4Alexander Zipprich5Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, GermanyElse Kröner Graduate School for Medical Students “Jena School for Ageing Medicine (JSAM)”, Jena University Hospital, Jena, GermanyDepartment of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, GermanyDepartment of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, GermanyDepartment of Urology, Jena University Hospital, Jena, GermanyDepartment of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, GermanyIQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer initiation and progression has received increasing attention in recent years, especially in hepatocellular carcinoma (HCC), where the aberrant expression of IQGAPs is closely related to patient prognosis. IQGAP1 and 3 are upregulated and are considered oncogenes in HCC, while IQGAP2 is downregulated and functions as a tumor suppressor. This review details the three IQGAP isoforms and their respective structures. The expression and role of each protein in different liver diseases and mainly in HCC, as well as the underlying mechanisms, are also presented. This review also provides a reference for further studies on IQGAPs in HCC.https://www.frontiersin.org/articles/10.3389/fonc.2022.920652/fullIQGAPshepatocellular carcinomaHBVcytoskeletonsignal transduction |
| spellingShingle | Qingqing Dai Qingqing Dai Quratul Ain Michael Rooney Fei Song Alexander Zipprich Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma Frontiers in Oncology IQGAPs hepatocellular carcinoma HBV cytoskeleton signal transduction |
| title | Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma |
| title_full | Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma |
| title_fullStr | Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma |
| title_full_unstemmed | Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma |
| title_short | Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma |
| title_sort | role of iq motif containing gtpase activating proteins in hepatocellular carcinoma |
| topic | IQGAPs hepatocellular carcinoma HBV cytoskeleton signal transduction |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.920652/full |
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