Chemerin: A Functional Adipokine in Reproductive Health and Diseases
As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin and the cognate rece...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/8/1910 |
| _version_ | 1797432416785137664 |
|---|---|
| author | Ming Yu Yali Yang Chen Huang Lei Ge Li Xue Zhonglin Xiao Tianxia Xiao Huashan Zhao Peigen Ren Jian V. Zhang |
| author_facet | Ming Yu Yali Yang Chen Huang Lei Ge Li Xue Zhonglin Xiao Tianxia Xiao Huashan Zhao Peigen Ren Jian V. Zhang |
| author_sort | Ming Yu |
| collection | DOAJ |
| description | As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin and the cognate receptors are also expressed in the hypothalamus, pituitary gland, testis, ovary, and placenta. Accumulating studies suggest that chemerin participates in normal reproduction and underlies the pathological mechanisms of certain reproductive system diseases, including polycystic ovary syndrome (PCOS), preeclampsia, and breast cancer. Herein, we present a comprehensive review of the roles of the chemerin system in multiple reproductive processes and human reproductive diseases, with a brief discussion and perspectives on future clinical applications. |
| first_indexed | 2024-03-09T10:00:14Z |
| format | Article |
| id | doaj.art-349741e675064d4fa7bb0e2ca8be613d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:00:14Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-349741e675064d4fa7bb0e2ca8be613d2023-12-01T23:27:50ZengMDPI AGBiomedicines2227-90592022-08-01108191010.3390/biomedicines10081910Chemerin: A Functional Adipokine in Reproductive Health and DiseasesMing Yu0Yali Yang1Chen Huang2Lei Ge3Li Xue4Zhonglin Xiao5Tianxia Xiao6Huashan Zhao7Peigen Ren8Jian V. Zhang9Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaAs a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin and the cognate receptors are also expressed in the hypothalamus, pituitary gland, testis, ovary, and placenta. Accumulating studies suggest that chemerin participates in normal reproduction and underlies the pathological mechanisms of certain reproductive system diseases, including polycystic ovary syndrome (PCOS), preeclampsia, and breast cancer. Herein, we present a comprehensive review of the roles of the chemerin system in multiple reproductive processes and human reproductive diseases, with a brief discussion and perspectives on future clinical applications.https://www.mdpi.com/2227-9059/10/8/1910chemerinCMKLR1GPR1reproductionpregnancyPCOS |
| spellingShingle | Ming Yu Yali Yang Chen Huang Lei Ge Li Xue Zhonglin Xiao Tianxia Xiao Huashan Zhao Peigen Ren Jian V. Zhang Chemerin: A Functional Adipokine in Reproductive Health and Diseases Biomedicines chemerin CMKLR1 GPR1 reproduction pregnancy PCOS |
| title | Chemerin: A Functional Adipokine in Reproductive Health and Diseases |
| title_full | Chemerin: A Functional Adipokine in Reproductive Health and Diseases |
| title_fullStr | Chemerin: A Functional Adipokine in Reproductive Health and Diseases |
| title_full_unstemmed | Chemerin: A Functional Adipokine in Reproductive Health and Diseases |
| title_short | Chemerin: A Functional Adipokine in Reproductive Health and Diseases |
| title_sort | chemerin a functional adipokine in reproductive health and diseases |
| topic | chemerin CMKLR1 GPR1 reproduction pregnancy PCOS |
| url | https://www.mdpi.com/2227-9059/10/8/1910 |
| work_keys_str_mv | AT mingyu chemerinafunctionaladipokineinreproductivehealthanddiseases AT yaliyang chemerinafunctionaladipokineinreproductivehealthanddiseases AT chenhuang chemerinafunctionaladipokineinreproductivehealthanddiseases AT leige chemerinafunctionaladipokineinreproductivehealthanddiseases AT lixue chemerinafunctionaladipokineinreproductivehealthanddiseases AT zhonglinxiao chemerinafunctionaladipokineinreproductivehealthanddiseases AT tianxiaxiao chemerinafunctionaladipokineinreproductivehealthanddiseases AT huashanzhao chemerinafunctionaladipokineinreproductivehealthanddiseases AT peigenren chemerinafunctionaladipokineinreproductivehealthanddiseases AT jianvzhang chemerinafunctionaladipokineinreproductivehealthanddiseases |