The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil
Purpose To evaluate the significance of several risk factors for prostate cancer in a cohort of Brazilian men. Subjects and methods: Men ≥ 40 years-old participating in a prostate cancer screening program between December 2006 and April 2011 in the city of Curitiba, Brazil, were evaluated to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2012-12-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000600769&lng=en&tlng=en |
| _version_ | 1811264438895902720 |
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| author | Frederico R. Romero Antonio W. Romero Rui Manuel S. de Almeida Fernando Cesar de Oliveira Jr. Renato Tambara Filho |
| author_facet | Frederico R. Romero Antonio W. Romero Rui Manuel S. de Almeida Fernando Cesar de Oliveira Jr. Renato Tambara Filho |
| author_sort | Frederico R. Romero |
| collection | DOAJ |
| description | Purpose To evaluate the significance of several risk factors for prostate cancer in a cohort of Brazilian men. Subjects and methods: Men ≥ 40 years-old participating in a prostate cancer screening program between December 2006 and April 2011 in the city of Curitiba, Brazil, were evaluated to determine the prevalence, relative risk (RR) and 95% CI of prostate cancer according to age, race, ethnicity, family history of prostate cancer, educational level, and history of vasectomy, increased blood pressure, diabetes mellitus, and urethritis. Results In 2121 men included in this study, prostate cancer prevalence was 0.6% for men between 40-49 years versus 2.0% (adjusted RR = 2.58), 7.7% (adjusted RR = 5.76), and 8.4% (adjusted RR = 4.88) for men 50-59 years, 60-69 years, and ≥ 70 years, respectively (p < 0.05 to all). The prevalence of cancer was 5.1% in blacks versus 3.3% in whites (adjusted RR = 1.56, p > 0.05); 6.1% in African descendants, in comparison to 3.0% in non-African descendants (adjusted RR = 3.17, p < 0.05); 5.1% in men with a positive family history, compared to 2.5% in those with no family history (adjusted RR = 1.55, p > 0.05); and 4.8% in participants with incomplete elementary school level or lower, compared to 2.2% in men with complete elementary school level or higher education (adjusted RR = 1.85, p > 0.05). Men with/without history of vasectomy, increased blood pressure, diabetes, and urethritis had a prostate cancer prevalence of 0.8%/3.0% (adjusted RR = 0.23, p > 0.05), 3.8%/2.2% (adjusted RR = 1.16, p > 0.05), 3.7%/2.6% (adjusted RR = 1.39, p > 0.05), and 2.6%/2.6% (adjusted RR = 0.99, p > 0.05), respectively. Conclusions Risk factors associated with an increased prevalence of prostate cancer in this cohort included increasing age and African ethnicity. |
| first_indexed | 2024-04-12T20:04:23Z |
| format | Article |
| id | doaj.art-34987b4b8aae428cbbe8f0a7bec9fad3 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-12T20:04:23Z |
| publishDate | 2012-12-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-34987b4b8aae428cbbe8f0a7bec9fad32022-12-22T03:18:27ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192012-12-0138676977810.1590/1677-553820133806769S1677-55382012000600769The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in BrazilFrederico R. RomeroAntonio W. RomeroRui Manuel S. de AlmeidaFernando Cesar de Oliveira Jr.Renato Tambara FilhoPurpose To evaluate the significance of several risk factors for prostate cancer in a cohort of Brazilian men. Subjects and methods: Men ≥ 40 years-old participating in a prostate cancer screening program between December 2006 and April 2011 in the city of Curitiba, Brazil, were evaluated to determine the prevalence, relative risk (RR) and 95% CI of prostate cancer according to age, race, ethnicity, family history of prostate cancer, educational level, and history of vasectomy, increased blood pressure, diabetes mellitus, and urethritis. Results In 2121 men included in this study, prostate cancer prevalence was 0.6% for men between 40-49 years versus 2.0% (adjusted RR = 2.58), 7.7% (adjusted RR = 5.76), and 8.4% (adjusted RR = 4.88) for men 50-59 years, 60-69 years, and ≥ 70 years, respectively (p < 0.05 to all). The prevalence of cancer was 5.1% in blacks versus 3.3% in whites (adjusted RR = 1.56, p > 0.05); 6.1% in African descendants, in comparison to 3.0% in non-African descendants (adjusted RR = 3.17, p < 0.05); 5.1% in men with a positive family history, compared to 2.5% in those with no family history (adjusted RR = 1.55, p > 0.05); and 4.8% in participants with incomplete elementary school level or lower, compared to 2.2% in men with complete elementary school level or higher education (adjusted RR = 1.85, p > 0.05). Men with/without history of vasectomy, increased blood pressure, diabetes, and urethritis had a prostate cancer prevalence of 0.8%/3.0% (adjusted RR = 0.23, p > 0.05), 3.8%/2.2% (adjusted RR = 1.16, p > 0.05), 3.7%/2.6% (adjusted RR = 1.39, p > 0.05), and 2.6%/2.6% (adjusted RR = 0.99, p > 0.05), respectively. Conclusions Risk factors associated with an increased prevalence of prostate cancer in this cohort included increasing age and African ethnicity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000600769&lng=en&tlng=enEpidemiologyPopulation groupsPrevalenceProstatic Neoplasms |
| spellingShingle | Frederico R. Romero Antonio W. Romero Rui Manuel S. de Almeida Fernando Cesar de Oliveira Jr. Renato Tambara Filho The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil International Brazilian Journal of Urology Epidemiology Population groups Prevalence Prostatic Neoplasms |
| title | The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil |
| title_full | The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil |
| title_fullStr | The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil |
| title_full_unstemmed | The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil |
| title_short | The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil |
| title_sort | significance of biological environmental and social risk factors for prostate cancer in a cohort study in brazil |
| topic | Epidemiology Population groups Prevalence Prostatic Neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000600769&lng=en&tlng=en |
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