Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentia...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=925;epage=931;aulast=Shen |
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| author | Ling-ling Shen Ming-liang Jiang Si-si Liu Min-chun Cai Zhong-qiu Hong Li-qing Lin Yan-yan Xing Gui-lin Chen Rui Pan Li-juan Yang Ying Xu Jun Dong |
| author_facet | Ling-ling Shen Ming-liang Jiang Si-si Liu Min-chun Cai Zhong-qiu Hong Li-qing Lin Yan-yan Xing Gui-lin Chen Rui Pan Li-juan Yang Ying Xu Jun Dong |
| author_sort | Ling-ling Shen |
| collection | DOAJ |
| description | Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca 2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug. |
| first_indexed | 2024-12-23T10:53:11Z |
| format | Article |
| id | doaj.art-3498d46de1e44b288c838d17d545a978 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-23T10:53:11Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-3498d46de1e44b288c838d17d545a9782022-12-21T17:49:51ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110692593110.4103/1673-5374.158358Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loopLing-ling ShenMing-liang JiangSi-si LiuMin-chun CaiZhong-qiu HongLi-qing LinYan-yan XingGui-lin ChenRui PanLi-juan YangYing XuJun DongCurcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca 2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=925;epage=931;aulast=Shenmicrotubuleaxonkinesin-5Eg5regenerationmonastrolmolecular motor proteinagingneurodegenerative disorderstelomere shorteningMSCscellular therapytraumatic brain injuryspinal cord injuriesdual diagnosisdiagnosiscomplicationsrehabilitationpost-concussion syndromebrain concussionblood brain barrierphage displaypeptide librarynanocarriertargetingSchwann cellsneurite outgrowthneuromuscular junction (NMJ)multiple sclerosisTGF-β/BMP-7/Smad signalingmyogenic differentiationTrf3tumor suppressionnerve regenerationbone marrow mesenchymal stem cellscerebral ischemiatail vein injectionmiddle cerebral artery occlusioncell therapyneuroprotectionnerve regenerationbrain injuryneuroimagingferumoxytolsuperparamagnetic iron oxide particleshuman adipose-derived stem cellsmiddle cerebral artery occlusionintracerebral injectionmagnetic resonance imagingenhanced susceptibility-weighted angiography imagemodified neurological severity scoresratsPrussian blue stainingneural regenerationneural regenerationnon-invasive brain stimulationtranscranial magnetic stimulationneurotrophic factorbrain-derived neurotrophic factorneuroplasticityhippocampusagingcognitive functionnerve regenerationcurcuminneuronsHIV-1 gp120 V3 loopplasticityHIV-associated neurocognitive disordersoutput/input curvelong-term potentiationexcitatory postsynaptic potentialpaired-pulse facilitationCa 2+synaptosomeNSFC grantsneural regeneration |
| spellingShingle | Ling-ling Shen Ming-liang Jiang Si-si Liu Min-chun Cai Zhong-qiu Hong Li-qing Lin Yan-yan Xing Gui-lin Chen Rui Pan Li-juan Yang Ying Xu Jun Dong Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop Neural Regeneration Research microtubule axon kinesin-5 Eg5 regeneration monastrol molecular motor protein aging neurodegenerative disorders telomere shortening MSCs cellular therapy traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion blood brain barrier phage display peptide library nanocarrier targeting Schwann cells neurite outgrowth neuromuscular junction (NMJ) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression nerve regeneration bone marrow mesenchymal stem cells cerebral ischemia tail vein injection middle cerebral artery occlusion cell therapy neuroprotection nerve regeneration brain injury neuroimaging ferumoxytol superparamagnetic iron oxide particles human adipose-derived stem cells middle cerebral artery occlusion intracerebral injection magnetic resonance imaging enhanced susceptibility-weighted angiography image modified neurological severity scores rats Prussian blue staining neural regeneration neural regeneration non-invasive brain stimulation transcranial magnetic stimulation neurotrophic factor brain-derived neurotrophic factor neuroplasticity hippocampus aging cognitive function nerve regeneration curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca 2+ synaptosome NSFC grants neural regeneration |
| title | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
| title_full | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
| title_fullStr | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
| title_full_unstemmed | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
| title_short | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
| title_sort | curcumin improves synaptic plasticity impairment induced by hiv 1gp120 v3 loop |
| topic | microtubule axon kinesin-5 Eg5 regeneration monastrol molecular motor protein aging neurodegenerative disorders telomere shortening MSCs cellular therapy traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion blood brain barrier phage display peptide library nanocarrier targeting Schwann cells neurite outgrowth neuromuscular junction (NMJ) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression nerve regeneration bone marrow mesenchymal stem cells cerebral ischemia tail vein injection middle cerebral artery occlusion cell therapy neuroprotection nerve regeneration brain injury neuroimaging ferumoxytol superparamagnetic iron oxide particles human adipose-derived stem cells middle cerebral artery occlusion intracerebral injection magnetic resonance imaging enhanced susceptibility-weighted angiography image modified neurological severity scores rats Prussian blue staining neural regeneration neural regeneration non-invasive brain stimulation transcranial magnetic stimulation neurotrophic factor brain-derived neurotrophic factor neuroplasticity hippocampus aging cognitive function nerve regeneration curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca 2+ synaptosome NSFC grants neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=925;epage=931;aulast=Shen |
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