Cancer Treatment: An Epigenetic View
Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2020-06-01
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| Series: | Global Medical Genetics |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713610 |
| _version_ | 1811313070282113024 |
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| author | Cansu Aydin Rasime Kalkan |
| author_facet | Cansu Aydin Rasime Kalkan |
| author_sort | Cansu Aydin |
| collection | DOAJ |
| description | Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics. |
| first_indexed | 2024-04-13T10:47:45Z |
| format | Article |
| id | doaj.art-349925a2609b48f6bcbdded3dcd046b7 |
| institution | Directory Open Access Journal |
| issn | 2699-9404 |
| language | English |
| last_indexed | 2024-04-13T10:47:45Z |
| publishDate | 2020-06-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj.art-349925a2609b48f6bcbdded3dcd046b72022-12-22T02:49:44ZengGeorg Thieme Verlag KGGlobal Medical Genetics2699-94042020-06-01070100300710.1055/s-0040-1713610Cancer Treatment: An Epigenetic ViewCansu Aydin0Rasime Kalkan1Department of Molecular Biology and Genetics, Faculty of Medicine, Trakya University, Merkez/Edirne, TurkeyDepartment of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Turkish Republic of Northern CyprusCancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713610cancertreatmentepigeneticsepidrugsmethylation |
| spellingShingle | Cansu Aydin Rasime Kalkan Cancer Treatment: An Epigenetic View Global Medical Genetics cancer treatment epigenetics epidrugs methylation |
| title | Cancer Treatment: An Epigenetic View |
| title_full | Cancer Treatment: An Epigenetic View |
| title_fullStr | Cancer Treatment: An Epigenetic View |
| title_full_unstemmed | Cancer Treatment: An Epigenetic View |
| title_short | Cancer Treatment: An Epigenetic View |
| title_sort | cancer treatment an epigenetic view |
| topic | cancer treatment epigenetics epidrugs methylation |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713610 |
| work_keys_str_mv | AT cansuaydin cancertreatmentanepigeneticview AT rasimekalkan cancertreatmentanepigeneticview |