A novel mRNA vaccine, SYS6006, against SARS-CoV-2

A novel mRNA vaccine, SYS6006, against SARS-CoV-2

The development of vaccines that can efficiently prevent the infection of SARS-CoV-2 is necessary to fight the COVID-19 epidemic. mRNA vaccine has been proven to induce strong humoral and cellular immunity against SARS-CoV-2. Here, we studied the immunogenicity and protection efficacy of a novel mRN...

Full description

Bibliographic Details
Main Authors:	Ke Xu, Wenwen Lei, Bin Kang, Hanyu Yang, Yajuan Wang, Yanli Lu, Lu Lv, Yufei Sun, Jing Zhang, Xiaolin Wang, Mengjie Yang, Mo Dan, Guizhen Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Immunology
Subjects:	mRNA vaccine SARS-CoV-2 Omicron variant spike protein neutralizing antibody T cell immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051576/full

Similar Items

Safety and immunogenicity of a SARS-CoV-2 mRNA vaccine (SYS6006) in minks, cats, blue foxes, and raccoon dogs
by: Hong Huo, et al.
Published: (2024-09-01)

The safety, immunogenicity, and efficacy of heterologous boosting with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: a randomized, open-label, active-controlled phase 3 trial
by: Chunhua Zhou, et al.
Published: (2024-12-01)

Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-controlled and dose-escalation phase 1 clinical trials
by: Gui-Ling Chen, et al.
Published: (2023-12-01)

Development and application of an uncapped mRNA platform
by: Xiaodi Zheng, et al.
Published: (2025-12-01)

Differentiating Cell Entry Potentials of SARS-CoV-2 Omicron Subvariants on Human Lung Epithelium Cells
by: Revansiddha H. Katte, et al.
Published: (2024-03-01)

The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study
by: Amy Ming-Fang Yen, et al.
Published: (2022-11-01)

Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
by: Yi Wu, et al.
Published: (2025-02-01)

Real-World Association Between mRNA Vaccination and Infection From the Omicron Strain of SARS-CoV-2: A Population-Level Analysis
by: Allison P. Plaxco, MPH, et al.
Published: (2022-09-01)

S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines
by: Yong-Sik Bong, et al.
Published: (2025-01-01)

Computational analysis of interior mutations of SARS-CoV-2 Spike protein suggest a balance of protein stability and S2: S1 separation propensity
by: Zhen-lu Li, et al.
Published: (2022-01-01)

Understanding Omicron: Transmissibility, immune evasion and antiviral intervention
by: Markus Hoffmann, et al.
Published: (2022-05-01)

The impact of S2 mutations on Omicron SARS-CoV-2 cell surface expression and fusogenicity
by: Alba Escalera, et al.
Published: (2024-12-01)

PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge
by: Yongxiang Zhao, et al.
Published: (2024-02-01)

Design and Characterization of a New Formulation for the Delivery of COVID-19-mRNA Vaccine to the Nasal Mucosa
by: Ayça Altay Benetti, et al.
Published: (2024-04-01)

The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice
by: Zhiyin An, et al.
Published: (2023-05-01)

Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy
by: Yuxiang Zhao, et al.
Published: (2023-10-01)

Combinative workflow for mRNA vaccine development
by: Renuka Khanzode, et al.
Published: (2024-09-01)

Association Between mRNA Vaccination and Infection From SARS-CoV-2 During the Delta and Omicron BA.1 Waves: A Population-Level Analysis
by: Allison P. Plaxco, MPH, et al.
Published: (2023-12-01)

Proteomic Approach for Comparative Analysis of the Spike Protein of SARS-CoV-2 Omicron (B.1.1.529) Variant and Other Pango Lineages
by: Mukul Jain, et al.
Published: (2022-10-01)

Immune Evasion of SARS-CoV-2 Omicron Subvariants
by: Hanzhong Ke, et al.
Published: (2022-09-01)

Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies
by: Jing Lu, et al.
Published: (2024-12-01)

Screening of Omicron Virus Strain by Quantifying the Spike Protein Content
by: Zhenyu He, et al.
Published: (2024-06-01)

mRNA nuclear export: how mRNA identity features distinguish functional RNAs from junk transcripts
by: Alexander F. Palazzo, et al.
Published: (2024-12-01)

Immunization with a novel mRNA vaccine, TGGT1_216200 mRNA-LNP, prolongs survival time in BALB/c mice against acute toxoplasmosis
by: Yizhuo Zhang, et al.
Published: (2023-04-01)

Methods for teaching skills 6006D [electronic resource]

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48
by: Wenqi Wang, et al.
Published: (2024-10-01)

Omicron SARS-CoV-2 Variant Spike Protein Shows an Increased Affinity to the Human ACE2 Receptor: An In Silico Analysis
by: Joseph Thomas Ortega, et al.
Published: (2021-12-01)

Effectiveness of COVID-19 Vaccine Booster Shot Compared with Non-Booster: A Meta-Analysis
by: Yajuan Zhu, et al.
Published: (2022-08-01)

Antibody Response to the BA.5 Bivalent Vaccine Shot: a Two-Year Follow-Up Study following Initial COVID-19 mRNA Vaccination
by: Yosuke Hirotsu, et al.
Published: (2023-06-01)

Vaccines against COVID-19: Priority to mRNA-Based Formulations
by: Steve Pascolo
Published: (2021-10-01)

Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine
by: Qian Chen, et al.
Published: (2023-04-01)

Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
by: Tudor Emanuel Fertig, et al.
Published: (2022-06-01)

Nuclear translocation of spike mRNA and protein is a novel feature of SARS-CoV-2
by: Sarah Sattar, et al.
Published: (2023-01-01)

Identification and validation of a major quantitative trait locus for spike length and compactness in the wheat (Triticum aestivum L.) line Chuanyu12D7
by: Mingxiu Wang, et al.
Published: (2023-07-01)

COVID-19 Vaccine Booster Dose Fails to Enhance Antibody Response to Omicron Variant in Reinfected Healthcare Workers
by: Leire Fernández-Ciriza, et al.
Published: (2025-01-01)

Probabilistic Classification Method of Spiking Neural Network Based on Multi-Labeling of Neurons
by: Mingyu Sung, et al.
Published: (2023-03-01)

Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
by: Dongrong Yi, et al.
Published: (2025-02-01)

SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entry
by: Yasuteru Sakurai, et al.
Published: (2024-09-01)

Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
by: Katy Cornish, et al.
Published: (2024-06-01)

An Insight Based on Computational Analysis of the Interaction between the Receptor-Binding Domain of the Omicron Variants and Human Angiotensin-Converting Enzyme 2
by: Ismail Celik, et al.
Published: (2022-05-01)