Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages

Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages

Abstract Macrophage dysfunction has been well-described in Cystic Fibrosis (CF) and may contribute to bacterial persistence in the lung. Whether CF macrophage dysfunction is related directly to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in macrophages or an indirect consequence of ch...

Full description

Bibliographic Details
Main Authors:	Daniel S. Aridgides, Diane L. Mellinger, Lorraine L. Gwilt, Thomas H. Hampton, Dallas L. Mould, Deborah A. Hogan, Alix Ashare
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-38300-9

Similar Items

Fertility, Pregnancy and Lactation Considerations for Women with CF in the CFTR Modulator Era
by: Raksha Jain, et al.
Published: (2021-05-01)

Multicenter intestinal current measurements in rectal biopsies from CF and non-CF subjects to monitor CFTR function.
by: John P Clancy, et al.
Published: (2013-01-01)

CF-like lung disease associated with CFTR splicing variant
by: Haston Christina, et al.
Published: (2000-12-01)

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
by: Gill, DR, et al.
Published: (2010)

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant
by: Dallas L Mould, et al.
Published: (2022-05-01)

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene
by: Jie Xu, et al.
Published: (2021-01-01)

Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation.
by: Steven M Rowe, et al.
Published: (2013-01-01)

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.
by: Broackes-Carter, F, et al.
Published: (2002)

Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients
by: Naughton Kathleen M, et al.
Published: (2010-10-01)

Two novel and correlated CF-causing insertions in the (TG)mTn tract of the CFTR gene.
by: Silvia Pierandrei, et al.
Published: (2019-01-01)

Exposure to extracellular vesicles from Pseudomonas aeruginosa result in loss of DNA methylation at enhancer and DNase hypersensitive site regions in lung macrophages
by: Min Kyung Lee, et al.
Published: (2021-11-01)

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells
by: Mieke Veltman, et al.
Published: (2021-02-01)

Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
by: Schäfer, Jürgen, et al.
Published: (2018)

Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
by: Jürgen Schäfer, et al.
Published: (2018-05-01)

Demographic characteristics, clinical and laboratory features, and the distribution of pathogenic variants in the CFTR gene in the Cypriot cystic fibrosis (CF) population demonstrate the utility of a national CF patient registry
by: Panayiotis K. Yiallouros, et al.
Published: (2021-10-01)

LASER-INDUCED FLUORESCENCE DETECTION OF CF AND CF2 RADICALS IN A CF4/O2 PLASMA
by: Booth, J, et al.
Published: (1987)

Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(diazo-2,2,2-trifluoroethyl)arenes.
by: Emer, E, et al.
Published: (2014)

Geological hazard susceptibility evaluation based on CF and CF-LR model
by: Shuiyun TU, et al.
Published: (2022-04-01)

Impact of vitamin D status on CF and non-CF bronchiectasis outcomes
by: Heba A. Ali, et al.
Published: (2022-01-01)

CF 2000 ECUMÊNICA: EPISÓDIO OU NOVA FASE DA CF?
by: Gabriele Cipriani
Published: (2001-01-01)

CF 2000 ECUMÊNICA: EPISÓDIO OU NOVA FASE DA CF?
by: Gabriele Cipriani
Published: (2001-01-01)

Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR.
by: Robert L Young, et al.
Published: (2011-01-01)

SPATIALLY AND TEMPORALLY RESOLVED LASER-INDUCED FLUORESCENCE MEASUREMENTS OF CF2 AND CF RADICALS IN A CF4 RF PLASMA
by: Booth, J, et al.
Published: (1989)

The Effect of Resin Matrix on the Properties of CF/PEI and CF/PAEK Thermoplastic Composites
by: Wencai Wang, et al.
Published: (2023-01-01)

Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin
by: Brankica Filipic, et al.
Published: (2017-05-01)

SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.
by: Shama Ahmad, et al.
Published: (2011-01-01)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CF
by: Davies, J, et al.
Published: (2011)

Extensive <i>CFTR</i> Gene Analysis Revealed a Higher Occurrence of Cystic Fibrosis Transmembrane Regulator-Related Disorders (CFTR-RD) among CF Carriers
by: Maria Valeria Esposito, et al.
Published: (2020-11-01)

Delivery of genes into the CF airway
by: Gill, D, et al.
Published: (2014)

Psychological Impact of NBS for CF
by: Jane Chudleigh, et al.
Published: (2020-03-01)

Class 1 CF Mutations
by: Michael eWilschanski
Published: (2012-06-01)

CfA3: 185 TYPE Ia SUPERNOVA LIGHT CURVES FROM THE CfA
by: Krauss, Miriam, et al.
Published: (2015)

Comparison of the Hypersensitive Response Induced by the Tomato Cf-4 and Cf-9 Genes in Nicotiana spp.
by: Colwyn M. Thomas, et al.
Published: (2000-04-01)

Comparisons of resistance of CF and Non-CF pathogens to Hydrogen Peroxide and Hypochlorous Acid Oxidants <it>In Vitro</it>
by: Ledet Elisa M, et al.
Published: (2011-05-01)

CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies
by: Samuel L. Neff, et al.
Published: (2022-06-01)

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators
by: Danya Muilwijk, et al.
Published: (2021-12-01)

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis
by: Youdinghuan Chen, et al.
Published: (2018-12-01)

General, Practical and Selective Oxidation Protocol for CF<sub>3</sub>S into CF<sub>3</sub>S(O) Group
by: Liubov V. Sokolenko, et al.
Published: (2019-03-01)

CF2-bridged C60 dimers and their optical transitions
by: Dallas, P, et al.
Published: (2017)

Synthesis and Reactivity of Mn–CF3 Complexes
by: Alex L. Daniels, et al.
Published: (2019-01-01)