Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy.
Chronic alcohol dependence has been associated with disturbed behavior, cerebral atrophy and a low plasma concentration of docosahexaenoic acid (DHA, 22∶6n-3), particularly if liver disease is present. In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, sug...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3788756?pdf=render |
| _version_ | 1818838999643455488 |
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| author | John C Umhau Weiyin Zhou Shantalaxmi Thada James Demar Nahed Hussein Abesh K Bhattacharjee Kaizong Ma Sharon Majchrzak-Hong Peter Herscovitch Norman Salem Abigail Urish Joseph R Hibbeln Stephen C Cunnane Stanley I Rapoport Jussi Hirvonen |
| author_facet | John C Umhau Weiyin Zhou Shantalaxmi Thada James Demar Nahed Hussein Abesh K Bhattacharjee Kaizong Ma Sharon Majchrzak-Hong Peter Herscovitch Norman Salem Abigail Urish Joseph R Hibbeln Stephen C Cunnane Stanley I Rapoport Jussi Hirvonen |
| author_sort | John C Umhau |
| collection | DOAJ |
| description | Chronic alcohol dependence has been associated with disturbed behavior, cerebral atrophy and a low plasma concentration of docosahexaenoic acid (DHA, 22∶6n-3), particularly if liver disease is present. In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, suggesting disturbed brain DHA metabolism. We hypothesized that brain DHA metabolism also is abnormal in chronic alcoholics.We compared 15 non-smoking chronic alcoholics, studied within 7 days of their last drink, with 22 non-smoking healthy controls. Using published neuroimaging methods with positron emission tomography (PET), we measured regional coefficients (K*) and rates (J(in)) of DHA incorporation from plasma into the brain of each group using [1-(11)C]DHA, and regional cerebral blood flow (rCBF) using [(15)O]water. Data were partial volume error corrected for brain atrophy. Plasma unesterified DHA concentration also was quantified.Mean K* for DHA was significantly and widely elevated by 10-20%, and rCBF was elevated by 7%-34%, in alcoholics compared with controls. Unesterified plasma DHA did not differ significantly between groups nor did whole brain J(in), the product of K* and unesterified plasma DHA concentration.Significantly higher values of K* for DHA in alcoholics indicate increased brain avidity for DHA, thus a brain DHA metabolic deficit vis-à-vis plasma DHA availability. Higher rCBF in alcoholics suggests increased energy consumption. These changes may reflect a hypermetabolic state related to early alcohol withdrawal, or a general brain metabolic change in chronic alcoholics. |
| first_indexed | 2024-12-19T03:47:19Z |
| format | Article |
| id | doaj.art-349a61ee4a27497faa13b83a20432330 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T03:47:19Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-349a61ee4a27497faa13b83a204323302022-12-21T20:37:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7533310.1371/journal.pone.0075333Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy.John C UmhauWeiyin ZhouShantalaxmi ThadaJames DemarNahed HusseinAbesh K BhattacharjeeKaizong MaSharon Majchrzak-HongPeter HerscovitchNorman SalemAbigail UrishJoseph R HibbelnStephen C CunnaneStanley I RapoportJussi HirvonenChronic alcohol dependence has been associated with disturbed behavior, cerebral atrophy and a low plasma concentration of docosahexaenoic acid (DHA, 22∶6n-3), particularly if liver disease is present. In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, suggesting disturbed brain DHA metabolism. We hypothesized that brain DHA metabolism also is abnormal in chronic alcoholics.We compared 15 non-smoking chronic alcoholics, studied within 7 days of their last drink, with 22 non-smoking healthy controls. Using published neuroimaging methods with positron emission tomography (PET), we measured regional coefficients (K*) and rates (J(in)) of DHA incorporation from plasma into the brain of each group using [1-(11)C]DHA, and regional cerebral blood flow (rCBF) using [(15)O]water. Data were partial volume error corrected for brain atrophy. Plasma unesterified DHA concentration also was quantified.Mean K* for DHA was significantly and widely elevated by 10-20%, and rCBF was elevated by 7%-34%, in alcoholics compared with controls. Unesterified plasma DHA did not differ significantly between groups nor did whole brain J(in), the product of K* and unesterified plasma DHA concentration.Significantly higher values of K* for DHA in alcoholics indicate increased brain avidity for DHA, thus a brain DHA metabolic deficit vis-à-vis plasma DHA availability. Higher rCBF in alcoholics suggests increased energy consumption. These changes may reflect a hypermetabolic state related to early alcohol withdrawal, or a general brain metabolic change in chronic alcoholics.http://europepmc.org/articles/PMC3788756?pdf=render |
| spellingShingle | John C Umhau Weiyin Zhou Shantalaxmi Thada James Demar Nahed Hussein Abesh K Bhattacharjee Kaizong Ma Sharon Majchrzak-Hong Peter Herscovitch Norman Salem Abigail Urish Joseph R Hibbeln Stephen C Cunnane Stanley I Rapoport Jussi Hirvonen Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. PLoS ONE |
| title | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. |
| title_full | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. |
| title_fullStr | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. |
| title_full_unstemmed | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. |
| title_short | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. |
| title_sort | brain docosahexaenoic acid dha incorporation and blood flow are increased in chronic alcoholics a positron emission tomography study corrected for cerebral atrophy |
| url | http://europepmc.org/articles/PMC3788756?pdf=render |
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