Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML
The role of mTORC1 in AML has not yet been proven due to the mixed results of its inhibitors in clinical trials. Here the authors show the real-time dynamics of the mTORC1 pathway in association with AML growth and response to chemotherapy with fluorescent markers, providing guidance for timed inter...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20491-8 |
| _version_ | 1818997501705846784 |
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| author | Toshihiko Oki Francois Mercier Hiroki Kato Yookyung Jung Thomas O. McDonald Joel A. Spencer Michael C. Mazzola Nick van Gastel Charles P. Lin Franziska Michor Toshio Kitamura David T. Scadden |
| author_facet | Toshihiko Oki Francois Mercier Hiroki Kato Yookyung Jung Thomas O. McDonald Joel A. Spencer Michael C. Mazzola Nick van Gastel Charles P. Lin Franziska Michor Toshio Kitamura David T. Scadden |
| author_sort | Toshihiko Oki |
| collection | DOAJ |
| description | The role of mTORC1 in AML has not yet been proven due to the mixed results of its inhibitors in clinical trials. Here the authors show the real-time dynamics of the mTORC1 pathway in association with AML growth and response to chemotherapy with fluorescent markers, providing guidance for timed intervention with pathway-specific inhibitors. |
| first_indexed | 2024-12-20T21:46:38Z |
| format | Article |
| id | doaj.art-349ab8eb498d4321b364ef08df2b3bd9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:46:38Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-349ab8eb498d4321b364ef08df2b3bd92022-12-21T19:25:40ZengNature PortfolioNature Communications2041-17232021-01-0112111310.1038/s41467-020-20491-8Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AMLToshihiko Oki0Francois Mercier1Hiroki Kato2Yookyung Jung3Thomas O. McDonald4Joel A. Spencer5Michael C. Mazzola6Nick van Gastel7Charles P. Lin8Franziska Michor9Toshio Kitamura10David T. Scadden11Center for Regenerative Medicine, Massachusetts General HospitalCenter for Regenerative Medicine, Massachusetts General HospitalCenter for Regenerative Medicine, Massachusetts General HospitalCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General HospitalDepartment of Stem Cell and Regenerative Biology, Harvard UniversityHarvard Stem Cell Institute, Harvard UniversityCenter for Regenerative Medicine, Massachusetts General HospitalCenter for Regenerative Medicine, Massachusetts General HospitalHarvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDivision of Cellular Therapy, The Institute of Medical Science, University of TokyoCenter for Regenerative Medicine, Massachusetts General HospitalThe role of mTORC1 in AML has not yet been proven due to the mixed results of its inhibitors in clinical trials. Here the authors show the real-time dynamics of the mTORC1 pathway in association with AML growth and response to chemotherapy with fluorescent markers, providing guidance for timed intervention with pathway-specific inhibitors.https://doi.org/10.1038/s41467-020-20491-8 |
| spellingShingle | Toshihiko Oki Francois Mercier Hiroki Kato Yookyung Jung Thomas O. McDonald Joel A. Spencer Michael C. Mazzola Nick van Gastel Charles P. Lin Franziska Michor Toshio Kitamura David T. Scadden Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML Nature Communications |
| title | Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML |
| title_full | Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML |
| title_fullStr | Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML |
| title_full_unstemmed | Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML |
| title_short | Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML |
| title_sort | imaging dynamic mtorc1 pathway activity in vivo reveals marked shifts that support time specific inhibitor therapy in aml |
| url | https://doi.org/10.1038/s41467-020-20491-8 |
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