The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis
Metabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and development. However, research findings of the asso...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/11/1/20 |
| _version_ | 1797495730366054400 |
|---|---|
| author | Ivana Škrlec Jasminka Talapko Snježana Džijan Vera Cesar Nikolina Lazić Hrvoje Lepeduš |
| author_facet | Ivana Škrlec Jasminka Talapko Snježana Džijan Vera Cesar Nikolina Lazić Hrvoje Lepeduš |
| author_sort | Ivana Škrlec |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and development. However, research findings of the association between circadian rhythm gene polymorphisms and MetS and its comorbidities are not consistent. In this study, a review of the association of circadian clock gene polymorphisms with overall MetS risk was performed. In addition, a meta-analysis was performed to clarify the association between circadian clock gene polymorphisms and MetS susceptibility based on available data. The PubMed and Scopus databases were searched for studies reporting the association between circadian rhythm gene polymorphisms (ARNTL, BMAL1, CLOCK, CRY, PER, NPAS2, REV-ERBα, REV-ERBβ, and RORα) and MetS, and its comorbidities diabetes, obesity, and hypertension. Thirteen independent studies were analyzed with 17,381 subjects in total. The results revealed that the BMAL1 rs7950226 polymorphism was associated with an increased risk of MetS in the overall population. In contrast, the CLOCK rs1801260 and rs6850524 polymorphisms were not associated with MetS. This study suggests that some circadian rhythm gene polymorphisms might be associated with MetS in different populations and potentially used as predictive biomarkers for MetS. |
| first_indexed | 2024-03-10T01:53:48Z |
| format | Article |
| id | doaj.art-349dfe1653da470182644bbf32df6e02 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T01:53:48Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-349dfe1653da470182644bbf32df6e022023-11-23T12:59:49ZengMDPI AGBiology2079-77372021-12-011112010.3390/biology11010020The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-AnalysisIvana Škrlec0Jasminka Talapko1Snježana Džijan2Vera Cesar3Nikolina Lazić4Hrvoje Lepeduš5Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, CroatiaMetabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and development. However, research findings of the association between circadian rhythm gene polymorphisms and MetS and its comorbidities are not consistent. In this study, a review of the association of circadian clock gene polymorphisms with overall MetS risk was performed. In addition, a meta-analysis was performed to clarify the association between circadian clock gene polymorphisms and MetS susceptibility based on available data. The PubMed and Scopus databases were searched for studies reporting the association between circadian rhythm gene polymorphisms (ARNTL, BMAL1, CLOCK, CRY, PER, NPAS2, REV-ERBα, REV-ERBβ, and RORα) and MetS, and its comorbidities diabetes, obesity, and hypertension. Thirteen independent studies were analyzed with 17,381 subjects in total. The results revealed that the BMAL1 rs7950226 polymorphism was associated with an increased risk of MetS in the overall population. In contrast, the CLOCK rs1801260 and rs6850524 polymorphisms were not associated with MetS. This study suggests that some circadian rhythm gene polymorphisms might be associated with MetS in different populations and potentially used as predictive biomarkers for MetS.https://www.mdpi.com/2079-7737/11/1/20circadian clock geneshypertensionmetabolic syndrometype 2 diabetes mellitusobesity |
| spellingShingle | Ivana Škrlec Jasminka Talapko Snježana Džijan Vera Cesar Nikolina Lazić Hrvoje Lepeduš The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis Biology circadian clock genes hypertension metabolic syndrome type 2 diabetes mellitus obesity |
| title | The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis |
| title_full | The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis |
| title_fullStr | The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis |
| title_short | The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis |
| title_sort | association between circadian clock gene polymorphisms and metabolic syndrome a systematic review and meta analysis |
| topic | circadian clock genes hypertension metabolic syndrome type 2 diabetes mellitus obesity |
| url | https://www.mdpi.com/2079-7737/11/1/20 |
| work_keys_str_mv | AT ivanaskrlec theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT jasminkatalapko theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT snjezanadzijan theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT veracesar theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT nikolinalazic theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT hrvojelepedus theassociationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT ivanaskrlec associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT jasminkatalapko associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT snjezanadzijan associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT veracesar associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT nikolinalazic associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis AT hrvojelepedus associationbetweencircadianclockgenepolymorphismsandmetabolicsyndromeasystematicreviewandmetaanalysis |