<it>N</it>-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging

<it>N</it>-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging

<p>Abstract</p> <p>This project involved the synthesis of <it>N</it>-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, a...

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Bibliographic Details
Main Authors: Khil Myung S, Sharma Manju, Kim Sun Y, Kc Remant B, Bhattarai Shanta R, Hwang Pyoung H, Chung Gyung H, Kim Hak Y
Format: Article
Language:English
Published: BMC 2008-01-01
Series:Journal of Nanobiotechnology
Online Access:http://www.jnanobiotechnology.com/content/6/1/1
Description
Summary:<p>Abstract</p> <p>This project involved the synthesis of <it>N</it>-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells <it>in vitro </it>and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.</p>
ISSN:1477-3155

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