Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity
Diabetes mellitus (DM) is an important metabolic disease due to its worldwide increasing prevalence. Dendrobium nobile Lindl. is used in traditional Chinese medicine and has been reported to have antidiabetic activity. In this study, several extraction methods, including microwave-assisted extract...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2020-12-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://rdo.psu.ac.th/sjstweb/journal/42-6/18.pdf |
| _version_ | 1818112972156829696 |
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| author | Chattarika Pengdee Boonchoo Sritularak Waraporn Putalun |
| author_facet | Chattarika Pengdee Boonchoo Sritularak Waraporn Putalun |
| author_sort | Chattarika Pengdee |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is an important metabolic disease due to its worldwide increasing prevalence. Dendrobium
nobile Lindl. is used in traditional Chinese medicine and has been reported to have antidiabetic activity. In this study, several
extraction methods, including microwave-assisted extraction (MAE), were applied to D. nobile and the extracts were investigated
for α-glucosidase inhibition potency. The optimal MAE conditions maximizing α-glucosidase inhibition were 540 W power, 60
sec extraction time, 40 mL/g solvent-to-feed ratio, and three extraction cycles. Our results show that MAE of D. nobile gave
stronger inhibition of α-glucosidase with lower IC50 and faster extraction than the other extraction methods. IC50 of D. nobile
extract was related to phenolic content with correlation -0.878, indicating that phenolics were the active compounds inhibiting αglucosidase in these plant extracts. |
| first_indexed | 2024-12-11T03:27:25Z |
| format | Article |
| id | doaj.art-34a14ae11fc44af3bf3d78568aa0c097 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-12-11T03:27:25Z |
| publishDate | 2020-12-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-34a14ae11fc44af3bf3d78568aa0c0972022-12-22T01:22:28ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952020-12-014261304130910.14456/sjst-psu.2020.169Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activityChattarika Pengdee0Boonchoo Sritularak1Waraporn Putalun2Faculty of Pharmaceutical Sciences, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathum Wan, Bangkok, 10330 ThailandFaculty of Pharmaceutical Sciences, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandDiabetes mellitus (DM) is an important metabolic disease due to its worldwide increasing prevalence. Dendrobium nobile Lindl. is used in traditional Chinese medicine and has been reported to have antidiabetic activity. In this study, several extraction methods, including microwave-assisted extraction (MAE), were applied to D. nobile and the extracts were investigated for α-glucosidase inhibition potency. The optimal MAE conditions maximizing α-glucosidase inhibition were 540 W power, 60 sec extraction time, 40 mL/g solvent-to-feed ratio, and three extraction cycles. Our results show that MAE of D. nobile gave stronger inhibition of α-glucosidase with lower IC50 and faster extraction than the other extraction methods. IC50 of D. nobile extract was related to phenolic content with correlation -0.878, indicating that phenolics were the active compounds inhibiting αglucosidase in these plant extracts.https://rdo.psu.ac.th/sjstweb/journal/42-6/18.pdfdendrobium nobilemicrowave-assisted extractiontaguchiα-glucosidase inhibitory activity |
| spellingShingle | Chattarika Pengdee Boonchoo Sritularak Waraporn Putalun Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity Songklanakarin Journal of Science and Technology (SJST) dendrobium nobile microwave-assisted extraction taguchi α-glucosidase inhibitory activity |
| title | Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity |
| title_full | Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity |
| title_fullStr | Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity |
| title_full_unstemmed | Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity |
| title_short | Microwave-assisted extraction of Dendrobium nobile Lindl. and its α-glucosidase inhibitory activity |
| title_sort | microwave assisted extraction of dendrobium nobile lindl and its α glucosidase inhibitory activity |
| topic | dendrobium nobile microwave-assisted extraction taguchi α-glucosidase inhibitory activity |
| url | https://rdo.psu.ac.th/sjstweb/journal/42-6/18.pdf |
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