EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE
The results of the effect of pulse-periodic X-ray exposure (PPXE) generated by Sinus-150 accelerator on tumor and normal cells of mice have been presented. Chromosomal aberrations (metaphase analysis) of bone marrow cells were studied. Using the cultured Lewis lung carcinoma cell lines, the level of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/271 |
| _version_ | 1797875919437692928 |
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| author | М. А. Buldakov N. V. Litvyakov I. А. Klimov О. P. Kutenkov А. А. Melnikov М. А. Bolshakov V. V. Rostov N. V. Cherdyntseva |
| author_facet | М. А. Buldakov N. V. Litvyakov I. А. Klimov О. P. Kutenkov А. А. Melnikov М. А. Bolshakov V. V. Rostov N. V. Cherdyntseva |
| author_sort | М. А. Buldakov |
| collection | DOAJ |
| description | The results of the effect of pulse-periodic X-ray exposure (PPXE) generated by Sinus-150 accelerator on tumor and normal cells of mice have been presented. Chromosomal aberrations (metaphase analysis) of bone marrow cells were studied. Using the cultured Lewis lung carcinoma cell lines, the level of apoptotic cells and cells with high concentration of active oxygen forms (AOF) was assessed by the flow cytofluorometry analysis (FACSCantoII, BD). In vivo X-ray radiation in the pulse-periodic mode lead to the moderate increase in chromosomal aberrations of bone marrow cells of mice. PPXE induced apoptotic death in Lewis lung carcinoma cells in vitro due to AOF production. Dose-effect relation was not observed at the irradiation doses 0.2–1.0 Gy. The data obtained show that further studies are necessary to justify the use of PPXE in tumor therapy. |
| first_indexed | 2024-04-10T01:54:05Z |
| format | Article |
| id | doaj.art-34a301eedb8943a4bcb36f3d3f52ffc9 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:54:05Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-34a301eedb8943a4bcb36f3d3f52ffc92023-03-13T09:05:48ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01053438271EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICEМ. А. Buldakov0N. V. Litvyakov1I. А. Klimov2О. P. KutenkovА. А. Melnikov3М. А. Bolshakov4V. V. Rostov5N. V. Cherdyntseva6Томский НИИ онкологии Томский государственный университетТомский НИИ онкологии Томский государственный университетТомский НИИ онкологииТомский НИИ онкологииИнститут сильноточной электроники СО РАН, г. Томск Томский государственный университетИнститут сильноточной электроники СО РАН, г. Томск Томский государственный университетТомский НИИ онкологии Томский государственный университетThe results of the effect of pulse-periodic X-ray exposure (PPXE) generated by Sinus-150 accelerator on tumor and normal cells of mice have been presented. Chromosomal aberrations (metaphase analysis) of bone marrow cells were studied. Using the cultured Lewis lung carcinoma cell lines, the level of apoptotic cells and cells with high concentration of active oxygen forms (AOF) was assessed by the flow cytofluorometry analysis (FACSCantoII, BD). In vivo X-ray radiation in the pulse-periodic mode lead to the moderate increase in chromosomal aberrations of bone marrow cells of mice. PPXE induced apoptotic death in Lewis lung carcinoma cells in vitro due to AOF production. Dose-effect relation was not observed at the irradiation doses 0.2–1.0 Gy. The data obtained show that further studies are necessary to justify the use of PPXE in tumor therapy.https://www.siboncoj.ru/jour/article/view/271импульсно-периодическое рентгеновское излучениехромосомные аберрацииапоптозкостный мозгэкспериментальные опухоли |
| spellingShingle | М. А. Buldakov N. V. Litvyakov I. А. Klimov О. P. Kutenkov А. А. Melnikov М. А. Bolshakov V. V. Rostov N. V. Cherdyntseva EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE Сибирский онкологический журнал импульсно-периодическое рентгеновское излучение хромосомные аберрации апоптоз костный мозг экспериментальные опухоли |
| title | EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE |
| title_full | EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE |
| title_fullStr | EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE |
| title_full_unstemmed | EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE |
| title_short | EFFECT OF PULSE PERIODIC X-RAYS ON TUMOR AND BONE MARROW CELLS OF MICE |
| title_sort | effect of pulse periodic x rays on tumor and bone marrow cells of mice |
| topic | импульсно-периодическое рентгеновское излучение хромосомные аберрации апоптоз костный мозг экспериментальные опухоли |
| url | https://www.siboncoj.ru/jour/article/view/271 |
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